MIR6129

Summary

MIR6129 (microRNA 6129, HGNC:50220) is a microRNA gene on chromosome 17q21.32.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465137 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50220
Approved symbol	MIR6129
Name	microRNA 6129
Location	17q21.32
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6129
Ensembl gene	ENSG00000273500
Ensembl biotype	miRNA
Entrez	102465137
RNAcentral	URS000075D3F4 — miRNA, 109 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000616087

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000616087 — 1 exons

Exon	Start	End
ENSE00003746972	49288346	49288454

Expression profiles

Bgee: expression breadth broad, 82 present calls, max score 82.05.

Top tissues by expression

82 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
olfactory segment of nasal mucosa	UBERON:0005386	82.05	gold quality
blood	UBERON:0000178	75.63	gold quality
monocyte	CL:0000576	75.41	gold quality
calcaneal tendon	UBERON:0003701	74.88	gold quality
gastrocnemius	UBERON:0001388	74.27	gold quality
fundus of stomach	UBERON:0001160	73.62	gold quality
islet of Langerhans	UBERON:0000006	73.42	gold quality
lymph node	UBERON:0000029	73.12	gold quality
urinary bladder	UBERON:0001255	72.19	gold quality
body of pancreas	UBERON:0001150	72.18	gold quality
endometrium	UBERON:0001295	72.16	gold quality
heart left ventricle	UBERON:0002084	71.91	gold quality
stomach	UBERON:0000945	71.73	gold quality
body of stomach	UBERON:0001161	71.70	gold quality
heart	UBERON:0000948	71.24	gold quality
right lung	UBERON:0002167	70.13	gold quality
liver	UBERON:0002107	69.96	gold quality
Ammon’s horn	UBERON:0001954	69.80	gold quality
ascending aorta	UBERON:0001496	69.59	gold quality
muscle layer of sigmoid colon	UBERON:0035805	69.55	gold quality
thoracic aorta	UBERON:0001515	69.52	gold quality
tibial artery	UBERON:0007610	69.45	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	69.40	gold quality
right atrium auricular region	UBERON:0006631	69.40	gold quality
adrenal tissue	UBERON:0018303	69.37	gold quality
lower esophagus	UBERON:0013473	69.11	gold quality
lower esophagus muscularis layer	UBERON:0035833	69.06	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	69.06	gold quality
corpus callosum	UBERON:0002336	69.01	gold quality
colon	UBERON:0001155	68.93	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.32

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.