MIR6130

Summary

MIR6130 (microRNA 6130, HGNC:50156) is a microRNA gene on chromosome 21q21.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466967 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50156
Approved symbol	MIR6130
Name	microRNA 6130
Location	21q21.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6130
Ensembl gene	ENSG00000275469
Ensembl biotype	miRNA
Entrez	102466967
RNAcentral	URS000075ADF6 — miRNA, 109 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000619419

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000619419 — 1 exons

Exon	Start	End
ENSE00003741747	23079284	23079392

Expression profiles

Bgee: expression breadth tissue_specific, 4 present calls, max score 71.14.

Top tissues by expression

4 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
corpus callosum	UBERON:0002336	71.14	gold quality
right frontal lobe	UBERON:0002810	59.63	gold quality
testis	UBERON:0000473	51.16	gold quality
left testis	UBERON:0004533	45.94	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.32

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.