MIR6131

Summary

MIR6131 (microRNA 6131, HGNC:49929) is a microRNA gene on chromosome 5p15.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465138 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49929
Approved symbol	MIR6131
Name	microRNA 6131
Location	5p15.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6131
Ensembl gene	ENSG00000277073
Ensembl biotype	miRNA
Entrez	102465138
RNAcentral	URS000075A98A — miRNA, 109 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000611729

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000611729 — 1 exons

Exon	Start	End
ENSE00003740690	10478037	10478145

Expression profiles

Bgee: expression breadth broad, 59 present calls, max score 85.93.

Top tissues by expression

59 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right uterine tube	UBERON:0001302	85.93	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	82.05	gold quality
blood	UBERON:0000178	78.20	gold quality
bone marrow	UBERON:0002371	75.59	gold quality
gastrocnemius	UBERON:0001388	74.76	gold quality
fallopian tube	UBERON:0003889	73.27	gold quality
amygdala	UBERON:0001876	70.57	gold quality
body of pancreas	UBERON:0001150	70.48	gold quality
stomach	UBERON:0000945	70.31	gold quality
thoracic mammary gland	UBERON:0005200	69.28	gold quality
hypothalamus	UBERON:0001898	69.12	gold quality
adult mammalian kidney	UBERON:0000082	68.96	gold quality
multicellular organism	UBERON:0000468	68.72	gold quality
right lobe of liver	UBERON:0001114	68.69	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.40	gold quality
vagina	UBERON:0000996	68.12	gold quality
body of stomach	UBERON:0001161	68.12	gold quality
Ammon’s horn	UBERON:0001954	67.90	gold quality
omental fat pad	UBERON:0010414	67.65	gold quality
left adrenal gland cortex	UBERON:0035825	66.95	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.94	gold quality
tibial nerve	UBERON:0001323	66.85	gold quality
caudate nucleus	UBERON:0001873	66.74	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.59	gold quality
left uterine tube	UBERON:0001303	66.49	gold quality
right atrium auricular region	UBERON:0006631	66.47	gold quality
left adrenal gland	UBERON:0001234	66.30	gold quality
endometrium	UBERON:0001295	66.28	gold quality
right frontal lobe	UBERON:0002810	65.96	gold quality
prostate gland	UBERON:0002367	65.92	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.46

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.