MIR6132

Summary

MIR6132 (microRNA 6132, HGNC:50272) is a microRNA gene on chromosome 7q31.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466616 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50272
Approved symbol	MIR6132
Name	microRNA 6132
Location	7q31.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6132
Ensembl gene	ENSG00000283923
Ensembl biotype	miRNA
Entrez	102466616
RNAcentral	URS000075C834 — miRNA, 109 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000622083

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000622083 — 1 exons

Exon	Start	End
ENSE00003753677	117020211	117020319

Expression profiles

Bgee: expression breadth broad, 59 present calls, max score 82.04.

FANTOM5 (CAGE): breadth broad, TPM avg 5.6107 / max 272.2260, expressed in 735 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
80703	5.6107	735

Top tissues by expression

59 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adult mammalian kidney	UBERON:0000082	82.04	gold quality
muscle of leg	UBERON:0001383	75.70	gold quality
blood	UBERON:0000178	73.50	gold quality
gastrocnemius	UBERON:0001388	72.27	gold quality
body of pancreas	UBERON:0001150	69.48	gold quality
liver	UBERON:0002107	67.35	gold quality
skin of abdomen	UBERON:0001416	66.84	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	66.82	gold quality
adrenal gland	UBERON:0002369	66.68	gold quality
minor salivary gland	UBERON:0001830	65.74	gold quality
right atrium auricular region	UBERON:0006631	65.70	gold quality
Brodmann (1909) area 9	UBERON:0013540	65.41	gold quality
omental fat pad	UBERON:0010414	65.11	gold quality
body of stomach	UBERON:0001161	64.93	gold quality
corpus callosum	UBERON:0002336	64.69	gold quality
descending thoracic aorta	UBERON:0002345	64.58	gold quality
heart	UBERON:0000948	64.46	gold quality
skin of leg	UBERON:0001511	64.13	gold quality
amygdala	UBERON:0001876	63.90	gold quality
tibial artery	UBERON:0007610	63.74	gold quality
cerebellar hemisphere	UBERON:0002245	63.70	gold quality
right hemisphere of cerebellum	UBERON:0014890	63.19	gold quality
lung	UBERON:0002048	62.75	gold quality
substantia nigra	UBERON:0002038	62.66	gold quality
esophagus mucosa	UBERON:0002469	62.57	gold quality
intestine	UBERON:0000160	62.16	gold quality
stomach	UBERON:0000945	62.14	gold quality
subcutaneous adipose tissue	UBERON:0002190	61.83	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	61.77	gold quality
colon	UBERON:0001155	61.48	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.