MIR6133

Summary

MIR6133 (microRNA 6133, HGNC:50007) is a microRNA gene on chromosome 7q33.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465139 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50007
Approved symbol	MIR6133
Name	microRNA 6133
Location	7q33
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6133
Ensembl gene	ENSG00000276137
Ensembl biotype	miRNA
Entrez	102465139
RNAcentral	URS000075BC87 — miRNA, 108 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000617057

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000617057 — 1 exons

Exon	Start	End
ENSE00003724430	133290881	133290988

Expression profiles

Bgee: expression breadth broad, 52 present calls, max score 77.07.

Top tissues by expression

52 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney	UBERON:0002113	77.07	gold quality
monocyte	CL:0000576	76.38	gold quality
stomach	UBERON:0000945	76.14	gold quality
adult mammalian kidney	UBERON:0000082	75.92	gold quality
blood	UBERON:0000178	75.42	gold quality
gastrocnemius	UBERON:0001388	74.64	gold quality
heart	UBERON:0000948	74.09	gold quality
body of stomach	UBERON:0001161	72.94	gold quality
calcaneal tendon	UBERON:0003701	72.22	gold quality
urinary bladder	UBERON:0001255	71.16	gold quality
intestine	UBERON:0000160	71.02	gold quality
lung	UBERON:0002048	70.65	gold quality
heart left ventricle	UBERON:0002084	70.57	gold quality
ascending aorta	UBERON:0001496	69.81	gold quality
liver	UBERON:0002107	69.66	gold quality
skin of leg	UBERON:0001511	69.43	gold quality
body of pancreas	UBERON:0001150	68.96	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.55	gold quality
omental fat pad	UBERON:0010414	68.25	gold quality
left adrenal gland	UBERON:0001234	68.22	gold quality
prostate gland	UBERON:0002367	67.90	gold quality
hypothalamus	UBERON:0001898	67.81	gold quality
colon	UBERON:0001155	67.51	gold quality
right atrium auricular region	UBERON:0006631	67.19	gold quality
skin of abdomen	UBERON:0001416	67.15	gold quality
minor salivary gland	UBERON:0001830	66.75	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	66.70	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.43	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.34	gold quality
left ovary	UBERON:0002119	66.07	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.66

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Inhibitory Effect of a Human MicroRNA, miR-6133-5p, on the Fibrotic Activity of Hepatic Stellate Cells in Culture. (PMID:33019495)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.