MIR6134

Summary

MIR6134 (microRNA 6134, HGNC:49951) is a microRNA gene on chromosome Xp21.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465140 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49951
Approved symbol	MIR6134
Name	microRNA 6134
Location	Xp21.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6134
Ensembl gene	ENSG00000277569
Ensembl biotype	miRNA
Entrez	102465140
RNAcentral	URS000075A660 — miRNA, 109 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000617606

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000617606 — 1 exons

Exon	Start	End
ENSE00003753428	28495555	28495663

Expression profiles

Bgee: expression breadth tissue_specific, 3 present calls, max score 68.19.

Top tissues by expression

3 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
transverse colon	UBERON:0001157	68.19	gold quality
right frontal lobe	UBERON:0002810	51.71	gold quality
left testis	UBERON:0004533	45.16	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.