MIR614

Summary

MIR614 (microRNA 614, HGNC:32870) is a microRNA gene on chromosome 12p13.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693199 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32870
Approved symbol	MIR614
Name	microRNA 614
Location	12p13.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-614
Ensembl gene	ENSG00000283759
Ensembl biotype	miRNA
Entrez	693199
RNAcentral	URS000075BC23 — miRNA, 90 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385082

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385082 — 1 exons

Exon	Start	End
ENSE00001500088	12915829	12915918

Expression profiles

Bgee: expression breadth broad, 30 present calls, max score 76.23.

Top tissues by expression

30 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
prostate gland	UBERON:0002367	76.23	gold quality
heart left ventricle	UBERON:0002084	73.98	gold quality
right frontal lobe	UBERON:0002810	69.50	gold quality
gastrocnemius	UBERON:0001388	68.76	gold quality
blood	UBERON:0000178	67.82	gold quality
right hemisphere of cerebellum	UBERON:0014890	66.69	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	64.97	gold quality
Ammon’s horn	UBERON:0001954	63.62	gold quality
islet of Langerhans	UBERON:0000006	62.54	gold quality
lower esophagus muscularis layer	UBERON:0035833	62.51	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	61.76	gold quality
right lobe of liver	UBERON:0001114	61.49	gold quality
skin of leg	UBERON:0001511	61.30	gold quality
nucleus accumbens	UBERON:0001882	60.68	gold quality
cerebellar hemisphere	UBERON:0002245	60.05	gold quality
putamen	UBERON:0001874	59.52	gold quality
anterior cingulate cortex	UBERON:0009835	59.00	gold quality
muscle layer of sigmoid colon	UBERON:0035805	58.62	gold quality
hypothalamus	UBERON:0001898	57.84	gold quality
spleen	UBERON:0002106	56.18	gold quality
body of pancreas	UBERON:0001150	55.01	gold quality
tibial nerve	UBERON:0001323	52.81	gold quality
amygdala	UBERON:0001876	51.78	gold quality
omental fat pad	UBERON:0010414	51.14	gold quality
adenohypophysis	UBERON:0002196	50.31	gold quality
skin of abdomen	UBERON:0001416	49.22	gold quality
caudate nucleus	UBERON:0001873	45.70	gold quality
pituitary gland	UBERON:0000007	45.61	gold quality
subcutaneous adipose tissue	UBERON:0002190	43.35	silver quality
left testis	UBERON:0004533	33.46	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• MiR-614 inhibited cell invasion and proliferationa targeting PSA in lung cancer cells, PGCL3 (PMID:25342037)
• the data suggested that miR614 promoted cell proliferation and inhibited cell apoptosis of ovarian cancer (OC) cells by targeting PPP2R2A, and may therefore act as a potential target for OC therapy in the future. (PMID:29532877)
• miR614 Expression Enhances Breast Cancer Cell Motility. (PMID:33374314)
• Expression of miR-614 in gastric cancer and its effect on invasion and proliferation of gastric cancer cells HGC-27. (PMID:34076996)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.