MIR615

Summary

MIR615 (microRNA 615, HGNC:32871) is a microRNA gene on chromosome 12q13.13.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693200 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32871
Approved symbol	MIR615
Name	microRNA 615
Location	12q13.13
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-615
Ensembl gene	ENSG00000207571
Ensembl biotype	miRNA
Entrez	693200
RNAcentral	URS000070789A — miRNA, 96 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384839

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384839 — 1 exons

Exon	Start	End
ENSE00002719803	54033950	54034045

Expression profiles

Bgee: expression breadth broad, 51 present calls, max score 88.00.

Top tissues by expression

51 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	88.00	gold quality
skeletal muscle tissue	UBERON:0001134	83.38	gold quality
blood	UBERON:0000178	79.69	gold quality
muscle of leg	UBERON:0001383	75.52	gold quality
gastrocnemius	UBERON:0001388	73.71	gold quality
heart left ventricle	UBERON:0002084	71.64	gold quality
body of stomach	UBERON:0001161	70.91	gold quality
stomach	UBERON:0000945	70.50	gold quality
right adrenal gland	UBERON:0001233	70.46	gold quality
ascending aorta	UBERON:0001496	69.93	gold quality
thoracic aorta	UBERON:0001515	69.78	gold quality
tibial artery	UBERON:0007610	69.43	gold quality
right adrenal gland cortex	UBERON:0035827	68.58	gold quality
left adrenal gland cortex	UBERON:0035825	68.36	gold quality
myometrium	UBERON:0001296	68.23	gold quality
endometrium	UBERON:0001295	68.16	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.12	gold quality
right ovary	UBERON:0002118	67.99	gold quality
adult mammalian kidney	UBERON:0000082	67.75	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.68	gold quality
muscle layer of sigmoid colon	UBERON:0035805	67.28	gold quality
body of uterus	UBERON:0009853	67.22	gold quality
left ovary	UBERON:0002119	66.82	gold quality
left adrenal gland	UBERON:0001234	66.73	gold quality
transverse colon	UBERON:0001157	66.55	gold quality
skin of leg	UBERON:0001511	66.51	gold quality
colon	UBERON:0001155	66.36	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.13	gold quality
small intestine	UBERON:0002108	66.01	gold quality
esophagus mucosa	UBERON:0002469	65.88	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.07

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 35)

• These results showed that the presence of miR-615-3p repressed the expression of LCoR, a derepressor of peroxisome proliferator-activated receptor gamma (PPARgamma). (PMID:21565892)
• miR-615-5p acts as tumor-suppressor in hepatocellular carcinoma through targeting IGF-II. (PMID:22819824)
• demonstrate that miR-615-5p was abnormally downregulated in pancreatic ductal adenocarcinoma cells due to promoter hypermethylation, which limited its inhibition of IGF2 and other target genes (PMID:24769899)
• miR-615-5p inhibits pancreatic cancer cell proliferation, migration, and invasion by targeting AKT2 (PMID:25856297)
• Loss of miR615 expression is associated with Hepatocellular Carcinoma. (PMID:25987019)
• CDX2 inhibited pancreatic adenocarcinoma cell proliferation via promoting tumor suppressor miR-615-5p. Our findings suggested a potential molecular target for pancreatic adenocarcinoma therapy. (PMID:26269116)
• our results for the first time showed that miR-615-5p prevents proliferation and migration through negatively regulating SHMT2 in HCC. (PMID:26662310)
• miR-615-5p, is downregulated by KDM4B-mediated hypermethylation in its promoter, functions as a tumor suppressor by inhibiting RAB24 expression in hepatocellular carcinoma. miR-615-5p is an important epigenetically silenced miRNA involved in the Rab-Ras pathway in hepatocellular carcinoma. (PMID:27487123)
• miR-615-3p negatively regulates the osteogenic differentiation of hLF cells through post-transcriptionally suppressing osteogenic regulators GDF5 and FOXO1. (PMID:28460412)
• miR-615-5p represses IGF-1 R and attenuates natural killer cells cytotoxicity in hepatocellular carcinoma. (PMID:28747084)
• Both mir-615-3p and HOXC5 are activated upon differentiation, which constitute a feed-forward loop that coordinates transcriptional and post-transcriptional repression of hTERT during cellular differentiation. Deregulation of HOXC5 and mir-615-3p expression may contribute to the activation of hTERT in human cancers. (PMID:29311615)
• MiR-615 as a tumor suppressor by targeting cyclin D2 in prostate cancer. (PMID:29471894)
• Overexpression of CELF2 could reverse miR-615-3p’s oncogenic functions. (PMID:29501762)
• miR-615-3p played important roles in the regulation of NSCLC growth and metastasis by targeting IGF2. (PMID:29562959)
• miR-615 plays a tumor suppressor role in glioblastoma cell proliferation, migration and invasion by targeting EGFR expression. (PMID:29605294)
• Study demonstrated that HOTTIP expression was significantly upregulated in renal cell carcinoma (RCC) and was associated with a shorter survival. The inhibition of HOTTIP suppressed cell proliferation, migration and invasion in RCC. In addition, IFG-2 was found to be a direct target gene of HOTTIP. HOTTIP directly bound to miR-615 and effectively acted as a sponge for miR-615 to modulate the suppression of IFG-2. (PMID:30226576)
• LINC00657 might be involved in regulating esophageal squamous cell carcinoma (ESCC’s) response to radiation; and it functioned as an oncogene in ESCC by targeting miR-615-3p and JunB. (PMID:30227324)
• Long non-coding RNA Gm15290 promotes cell proliferation and invasion in lung cancer through directly interacting with and suppressing the tumor suppressor miR-615-5p. (PMID:30287504)
• CircRNA 100146 could interact with splicing factors and bind miR-361-3p and miR-615-5p. (PMID:30665425)
• miR-615-5p as an inhibitor of VEGF-AKT/eNOS-mediated endothelial cell angiogenic responses. (PMID:31092013)
• HOTTIP was upregulated and miR-615-3p was downregulated in non-small cell lung cancer (NSCLC) tissues and cells. Hypoxia induced glycolysis, increased HOTTIP and HMGB3 mRNA levels and repressed miR-615-3p expression in NSCLC cells. HOTTIP deficiency or miR-615-3p expression restoration repressed hypoxia-induced glycolysis. HOTTIP acted as a molecular sponge for miR-615-3p and HMGB3 was a direct target of miR-615-3p. (PMID:31422060)
• Elevated miR-615-3p Expression Promotes Proliferation and Migration of Prostate Cancer. (PMID:31539518)
• miR-615-3p promotes the epithelial-mesenchymal transition and metastasis of breast cancer by targeting PICK1/TGFBRI axis. (PMID:32336285)
• LncRNA HOTTIP promotes proliferation and inhibits apoptosis of gastric carcinoma cells via adsorbing miR-615-3p. (PMID:32633359)
• Long noncoding RNA HOTTIP promotes the metastatic potential of ovarian cancer through the regulation of the miR-615-3p/SMARCE1 pathway. (PMID:32783402)
• CircZNF609 is involved in the pathogenesis of focal segmental glomerulosclerosis by sponging miR-615-5p. (PMID:32800553)
• Clinical and In Silico Outcomes of the Expression of miR-130a-5p and miR-615-3p in Tumor Compared with Non-Tumor Adjacent Tissues of Patients with BC. (PMID:32972352)
• Hsa_circRNA_002144 promotes growth and metastasis of colorectal cancer through regulating miR-615-5p/LARP1/mTOR pathway. (PMID:33347535)
• The Influence of rs1859168 Polymorphism on Serum Expression of HOTTIP and Its Target miR-615-3p in Egyptian Patients with Breast Cancer. (PMID:34069089)
• Circular RNA hsa_circ_0004396 acts as a sponge of miR-615-5p to promote non-small cell lung cancer progression and radioresistance through the upregulation of P21-Activated Kinase 1. (PMID:35500159)
• MiRNA-615-3p Alleviates Oxidative Stress Injury of Human Cardiomyocytes Via PI3K/Akt Signaling by Targeting MEF2A. (PMID:35552173)
• Circ_0067997 boosted the growth while repressed the apoptosis of SGC-7901/DDP cells via repressing miR-615-5p/AKT1 pathway. (PMID:37005876)
• Pro-inflammatory Cytokines Promote the Occurrence and Development of Colitis-associated Colorectal Cancer by Inhibiting miR-615-5p. (PMID:37300504)
• miR615-3p inhibited FBLN1 and osteogenic differentiation of umbilical cord mesenchymal stem cells by associated with YTHDF2 in a m[6]A-miRNA interaction manner. (PMID:38353178)
• Circ-PITX1 promotes non-small-cell lung cancer progression through regulating ETS1 expression via miR-615-5p. (PMID:39138880)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.