MIR6165

Summary

MIR6165 (microRNA 6165, HGNC:50197) is a microRNA gene on chromosome 17q21.33.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465141 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50197
Approved symbol	MIR6165
Name	microRNA 6165
Location	17q21.33
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6165
Ensembl gene	ENSG00000277478
Ensembl biotype	miRNA
Entrez	102465141
RNAcentral	URS000075BB89 — ncRNA, 84 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000614803

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000614803 — 1 exons

Exon	Start	End
ENSE00003742846	49510817	49510900

Expression profiles

Bgee: expression breadth broad, 89 present calls, max score 95.18.

Top tissues by expression

89 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	95.18	gold quality
prefrontal cortex	UBERON:0000451	86.03	gold quality
tibial nerve	UBERON:0001323	84.57	gold quality
vermiform appendix	UBERON:0001154	79.12	gold quality
blood	UBERON:0000178	76.09	gold quality
placenta	UBERON:0001987	75.17	gold quality
gastrocnemius	UBERON:0001388	74.30	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	74.30	gold quality
right ovary	UBERON:0002118	74.24	gold quality
right atrium auricular region	UBERON:0006631	73.22	gold quality
stomach	UBERON:0000945	73.02	gold quality
fundus of stomach	UBERON:0001160	73.01	gold quality
body of stomach	UBERON:0001161	72.86	gold quality
calcaneal tendon	UBERON:0003701	72.46	gold quality
heart	UBERON:0000948	71.75	gold quality
heart left ventricle	UBERON:0002084	71.60	gold quality
amygdala	UBERON:0001876	71.29	gold quality
liver	UBERON:0002107	71.25	gold quality
caudate nucleus	UBERON:0001873	70.95	gold quality
body of pancreas	UBERON:0001150	70.39	gold quality
putamen	UBERON:0001874	70.30	gold quality
islet of Langerhans	UBERON:0000006	69.95	gold quality
ascending aorta	UBERON:0001496	69.86	gold quality
omental fat pad	UBERON:0010414	69.81	gold quality
thoracic aorta	UBERON:0001515	69.76	gold quality
right lobe of liver	UBERON:0001114	69.60	gold quality
adipose tissue	UBERON:0001013	69.27	gold quality
right frontal lobe	UBERON:0002810	69.17	gold quality
gall bladder	UBERON:0002110	69.16	gold quality
tibial artery	UBERON:0007610	68.86	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.68

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• hsa-miR-6165 expression affects differentiation of NT2 cells. (PMID:28956260)
• Hsa-miR-6165 downregulates insulin-like growth factor-1 receptor (IGF-1R) expression and enhances apoptosis in SW480 cells. (PMID:31702994)
• Circular RNA circ_0001459 accelerates hepatocellular carcinoma progression via the miR-6165/IGF1R axis. (PMID:35199365)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.