MIR617

Summary

MIR617 (microRNA 617, HGNC:32873) is a microRNA gene on chromosome 12q21.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693202 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32873
Approved symbol	MIR617
Name	microRNA 617
Location	12q21.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-617
Ensembl gene	ENSG00000207763
Ensembl biotype	miRNA
OMIM	621190
Entrez	693202
RNAcentral	URS000075D960 — miRNA, 97 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385030

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385030 — 1 exons

Exon	Start	End
ENSE00001500037	80832533	80832629

Expression profiles

Bgee: expression breadth broad, 49 present calls, max score 84.70.

Top tissues by expression

49 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	84.70	gold quality
liver	UBERON:0002107	82.11	gold quality
endometrium	UBERON:0001295	76.60	gold quality
adrenal tissue	UBERON:0018303	75.99	gold quality
heart	UBERON:0000948	75.88	gold quality
lymph node	UBERON:0000029	75.68	gold quality
gastrocnemius	UBERON:0001388	75.33	gold quality
bone marrow	UBERON:0002371	74.53	gold quality
monocyte	CL:0000576	74.14	gold quality
stomach	UBERON:0000945	72.81	gold quality
kidney	UBERON:0002113	71.63	gold quality
intestine	UBERON:0000160	71.55	gold quality
calcaneal tendon	UBERON:0003701	71.00	gold quality
lung	UBERON:0002048	69.72	gold quality
skin of leg	UBERON:0001511	69.11	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.99	gold quality
right atrium auricular region	UBERON:0006631	68.47	gold quality
myometrium	UBERON:0001296	67.74	gold quality
Ammon’s horn	UBERON:0001954	67.53	gold quality
minor salivary gland	UBERON:0001830	66.39	gold quality
tibial artery	UBERON:0007610	66.35	gold quality
left adrenal gland cortex	UBERON:0035825	66.23	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.57	gold quality
ascending aorta	UBERON:0001496	65.52	gold quality
anterior cingulate cortex	UBERON:0009835	65.15	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.93	gold quality
caudate nucleus	UBERON:0001873	64.91	gold quality
tibial nerve	UBERON:0001323	64.77	gold quality
left lobe of thyroid gland	UBERON:0001120	64.75	gold quality
omental fat pad	UBERON:0010414	64.43	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.99

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• miR-617 Promotes the Growth of IL-22-Stimulated Keratinocytes Through Regulating FOXO4 Expression. (PMID:33211221)
• MicroRNA 617 Targeting SERPINE1 Inhibited the Progression of Oral Squamous Cell Carcinoma. (PMID:33820852)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.