MIR618

Summary

MIR618 (microRNA 618, HGNC:32874) is a microRNA gene on chromosome 12q21.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693203 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32874
Approved symbol	MIR618
Name	microRNA 618
Location	12q21.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-618
Ensembl gene	ENSG00000208022
Ensembl biotype	miRNA
Entrez	693203
RNAcentral	URS000075D4B4 — miRNA, 98 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385287

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385287 — 1 exons

Exon	Start	End
ENSE00001500293	80935736	80935833

Expression profiles

Bgee: expression breadth broad, 53 present calls, max score 83.93.

Top tissues by expression

53 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	83.93	gold quality
right atrium auricular region	UBERON:0006631	81.11	gold quality
liver	UBERON:0002107	78.18	gold quality
monocyte	CL:0000576	76.87	gold quality
adult mammalian kidney	UBERON:0000082	75.05	gold quality
heart	UBERON:0000948	74.34	gold quality
muscle layer of sigmoid colon	UBERON:0035805	73.42	gold quality
bone marrow	UBERON:0002371	73.17	gold quality
gastrocnemius	UBERON:0001388	73.10	gold quality
kidney	UBERON:0002113	72.71	gold quality
esophagus mucosa	UBERON:0002469	71.93	gold quality
right lobe of liver	UBERON:0001114	71.83	gold quality
left coronary artery	UBERON:0001626	70.31	gold quality
left adrenal gland cortex	UBERON:0035825	69.60	gold quality
stomach	UBERON:0000945	68.87	gold quality
intestine	UBERON:0000160	68.85	gold quality
heart left ventricle	UBERON:0002084	68.40	gold quality
anterior cingulate cortex	UBERON:0009835	68.19	gold quality
lung	UBERON:0002048	67.36	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.29	gold quality
skin of leg	UBERON:0001511	66.87	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.47	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.91	gold quality
colon	UBERON:0001155	65.77	gold quality
endocervix	UBERON:0000458	65.76	gold quality
body of uterus	UBERON:0009853	64.94	gold quality
thoracic mammary gland	UBERON:0005200	64.91	gold quality
caudate nucleus	UBERON:0001873	64.81	gold quality
amygdala	UBERON:0001876	64.73	gold quality
spleen	UBERON:0002106	64.62	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 14)

• Implicate miR-618 in follicular lymphomagenesis, identify miR-618 as a potential risk biomarker for follicular lymphoma, and illuminate miR-618-regulated lymphomagenic pathways that can serve as therapeutic targets for follicular lymphoma. (PMID:24503492)
• Results described a growth-suppressive role of miR-618 in TC cells partially targeting the PI3K/Akt signaling pathway. (PMID:27453421)
• Up-regulation of miR-618 suppresses the development of plasmacytoid dendritic cells and increases their ability to secrete IFNalpha, potentially contributing to the type I IFN signature observed in systemic sclerosis patients. (PMID:28556560)
• our study revealed that polymorphism rs2682818 in miR-618 contributes to CRC susceptibility. (PMID:29533012)
• Circular RNA circ_0005230 was proved to be a sponge of miR-618, and expression of miR-618 could regulate CBX8 expression via targeting the 3’UTR of CBX8. (PMID:30504704)
• miR-618 expression levels downregulated in gastric cancer (GC) tissues. In vitro miR-618 suppressed the invasion and migration capacity of GC cells. TGF-beta2 was identified and confirmed as a downstream target of miR-618. Findings suggest that miR-618 may function as a tumor suppressor in GC and suppresses metastasis in GC by negatively regulating the transcriptional level of TGF-beta2. (PMID:30737902)
• Does miR-618 rs2682818 variant affect cancer susceptibility? Evidence from 10 case-control studies. (PMID:31383788)
• LINC00511 was confirmed to be beneficial for osteosarcoma development via sponging miR-618 and increasing MAEL expression (PMID:31386627)
• miR-618 rs2682818 C>A polymorphism decreases Hirschsprung disease risk in Chinese children. (PMID:32364585)
• Circulating miR-618 Has Prognostic Significance in Patients with Metastatic Colon Cancer. (PMID:33804070)
• Polymorphism rs2682818 participates in the progression of colorectal carcinoma via miR-618-TIMP1 regulatory axis. (PMID:34848810)
• Exosomal microRNA-618 derived from mesenchymal stem cells attenuate the progression of hepatic fibrosis by targeting Smad4. (PMID:35199612)
• CircRNA circ-ATAD1 suppresses miR-618 maturation to participate in colorectal cancer. (PMID:35505304)
• Correlation between the miR-618 rs2682818 C>A polymorphism and venous malformation susceptibility. (PMID:38804038)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.