MIR619

Summary

MIR619 (microRNA 619, HGNC:32875) is a microRNA gene on chromosome 12q24.11.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693204 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32875
Approved symbol	MIR619
Name	microRNA 619
Location	12q24.11
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-619
Ensembl gene	ENSG00000207622
Ensembl biotype	miRNA
Entrez	693204
RNAcentral	URS000075CDCE — miRNA, 99 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384890

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384890 — 1 exons

Exon	Start	End
ENSE00001499897	108836908	108837006

Expression profiles

Bgee: expression breadth broad, 75 present calls, max score 83.56.

Top tissues by expression

75 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.56	gold quality
adrenal tissue	UBERON:0018303	78.63	gold quality
monocyte	CL:0000576	76.89	gold quality
islet of Langerhans	UBERON:0000006	75.47	gold quality
blood	UBERON:0000178	75.45	gold quality
bone marrow	UBERON:0002371	74.66	gold quality
gastrocnemius	UBERON:0001388	74.27	gold quality
substantia nigra	UBERON:0002038	73.82	gold quality
leukocyte	CL:0000738	73.14	gold quality
kidney	UBERON:0002113	72.07	gold quality
heart left ventricle	UBERON:0002084	71.93	gold quality
myometrium	UBERON:0001296	71.21	gold quality
right lobe of thyroid gland	UBERON:0001119	71.19	gold quality
stomach	UBERON:0000945	70.82	gold quality
left coronary artery	UBERON:0001626	70.69	gold quality
heart	UBERON:0000948	69.88	gold quality
liver	UBERON:0002107	69.87	gold quality
corpus callosum	UBERON:0002336	69.72	gold quality
body of pancreas	UBERON:0001150	69.35	gold quality
left uterine tube	UBERON:0001303	69.15	gold quality
tibial artery	UBERON:0007610	69.13	gold quality
ectocervix	UBERON:0012249	68.97	gold quality
ascending aorta	UBERON:0001496	68.79	gold quality
intestine	UBERON:0000160	68.71	gold quality
thoracic aorta	UBERON:0001515	68.71	gold quality
descending thoracic aorta	UBERON:0002345	68.71	gold quality
colon	UBERON:0001155	68.57	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.37	gold quality
body of stomach	UBERON:0001161	68.36	gold quality
right frontal lobe	UBERON:0002810	68.31	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.80

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 8)

• Groups of mRNAs in which the ordering of the miR-619-5p, miR-5095, miR-5096, and miR-5585-3p binding sites differ were established (PMID:25162022)
• In prostatic cancer, there is a significant increase in plasma hsa-miR-619-5p and hsa-miR-1184 microRNA expression. (PMID:27265125)
• downregulation of miR-619-5p or HDAC3 overexpression reversed SBF2-AS1-silencing-caused suppression on proliferation and metastasis. (PMID:30912164)
• Tumor-derived exosomal miR-619-5p promotes tumor angiogenesis and metastasis through the inhibition of RCAN1.4. (PMID:32004570)
• LncRNA PVT1 promotes gemcitabine resistance of pancreatic cancer via activating Wnt/beta-catenin and autophagy pathway through modulating the miR-619-5p/Pygo2 and miR-619-5p/ATG14 axes. (PMID:32727463)
• LncRNA BCYRN1 inhibits glioma tumorigenesis by competitively binding with miR-619-5p to regulate CUEDC2 expression and the PTEN/AKT/p21 pathway. (PMID:32978519)
• Circ-FAT1 Up-Regulates FOSL2 Expression by Sponging miR-619-5p to Facilitate Colorectal Cancer Progression. (PMID:35034245)
• hsa_circRNA_BECN1 acts as a ceRNA to promote polycystic ovary syndrome progression by sponging the miR-619-5p/Rab5b axis. (PMID:37882757)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.