MIR620

Summary

MIR620 (microRNA 620, HGNC:32876) is a microRNA gene on chromosome 12q24.21.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693205 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32876
Approved symbol	MIR620
Name	microRNA 620
Location	12q24.21
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-620
Ensembl gene	ENSG00000207967
Ensembl biotype	miRNA
Entrez	693205
RNAcentral	URS000075BCD3 — miRNA, 95 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385232

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385232 — 1 exons

Exon	Start	End
ENSE00001500238	116148560	116148654

Expression profiles

Bgee: expression breadth broad, 57 present calls, max score 87.62.

Top tissues by expression

57 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney	UBERON:0002113	87.62	gold quality
adult mammalian kidney	UBERON:0000082	87.46	gold quality
blood	UBERON:0000178	82.76	gold quality
calcaneal tendon	UBERON:0003701	81.07	gold quality
adrenal tissue	UBERON:0018303	79.52	gold quality
stomach	UBERON:0000945	79.32	gold quality
monocyte	CL:0000576	77.17	gold quality
endometrium	UBERON:0001295	75.62	gold quality
liver	UBERON:0002107	73.86	gold quality
gastrocnemius	UBERON:0001388	73.72	gold quality
heart	UBERON:0000948	71.79	gold quality
body of stomach	UBERON:0001161	71.16	gold quality
intestine	UBERON:0000160	69.78	gold quality
tibial artery	UBERON:0007610	69.74	gold quality
adrenal gland	UBERON:0002369	69.40	gold quality
heart left ventricle	UBERON:0002084	69.39	gold quality
skin of abdomen	UBERON:0001416	68.53	gold quality
left lobe of thyroid gland	UBERON:0001120	68.42	gold quality
subcutaneous adipose tissue	UBERON:0002190	67.60	gold quality
right lobe of liver	UBERON:0001114	67.41	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.41	gold quality
right atrium auricular region	UBERON:0006631	67.35	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	67.19	gold quality
right adrenal gland	UBERON:0001233	67.17	gold quality
nucleus accumbens	UBERON:0001882	67.09	gold quality
left adrenal gland	UBERON:0001234	66.92	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.34	gold quality
lung	UBERON:0002048	65.81	gold quality
skin of leg	UBERON:0001511	65.58	gold quality
colon	UBERON:0001155	65.56	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.48

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 7)

• GPC5, a tumor suppressor, is regulated by miR-620 in lung adenocarcinoma. (PMID:24682381)
• circSMARCA5/miR-620 regulatory axis is involved in the development of CC and may serve as a potential therapy target. (PMID:30575898)
• MiRNA-620 promotes TGF-beta1-induced proliferation of airway smooth muscle cell through controlling PTEN/AKT signaling pathway. (PMID:32583575)
• Circ-ABCB10 acts as an oncogene in glioma cells via regulation of the miR-620/FABP5 axis. (PMID:32633377)
• Circ_0001666 affects miR-620/WNK2 axis to inhibit breast cancer progression. (PMID:34061329)
• LncRNA ATP1A1-AS1 inhibits cell proliferation and promotes cell apoptosis in thyroid carcinoma by regulating the miR-620/IRF2BP2 axis. (PMID:36002076)
• Exosomal circ_0037104 derived from Hu-MSCs inhibits cholangiocarcinoma progression by sponging miR-620 and targeting AFAP1. (PMID:38348717)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.