MIR621

Summary

MIR621 (microRNA 621, HGNC:32877) is a microRNA gene on chromosome 13q14.11.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693206 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32877
Approved symbol	MIR621
Name	microRNA 621
Location	13q14.11
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-621
Ensembl gene	ENSG00000207652
Ensembl biotype	miRNA
Entrez	693206
RNAcentral	URS00006D8030 — miRNA, 96 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384919

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384919 — 1 exons

Exon	Start	End
ENSE00001499926	40810766	40810861

Expression profiles

Bgee: expression breadth broad, 49 present calls, max score 80.58.

Top tissues by expression

49 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	80.58	gold quality
bone marrow	UBERON:0002371	80.05	gold quality
liver	UBERON:0002107	78.72	gold quality
myometrium	UBERON:0001296	74.51	gold quality
islet of Langerhans	UBERON:0000006	69.62	gold quality
vagina	UBERON:0000996	68.05	gold quality
hypothalamus	UBERON:0001898	67.36	gold quality
Ammon’s horn	UBERON:0001954	67.34	gold quality
muscle of leg	UBERON:0001383	66.15	gold quality
anterior cingulate cortex	UBERON:0009835	65.80	gold quality
lymph node	UBERON:0000029	65.38	gold quality
blood	UBERON:0000178	64.79	gold quality
transverse colon	UBERON:0001157	63.77	gold quality
prostate gland	UBERON:0002367	63.56	gold quality
gastrocnemius	UBERON:0001388	63.53	gold quality
lower esophagus muscularis layer	UBERON:0035833	63.16	gold quality
tibial artery	UBERON:0007610	62.93	gold quality
left ovary	UBERON:0002119	61.45	gold quality
right ovary	UBERON:0002118	60.88	gold quality
caudate nucleus	UBERON:0001873	60.45	gold quality
muscle layer of sigmoid colon	UBERON:0035805	60.32	gold quality
ascending aorta	UBERON:0001496	60.28	gold quality
adult mammalian kidney	UBERON:0000082	58.92	gold quality
heart left ventricle	UBERON:0002084	58.75	gold quality
left coronary artery	UBERON:0001626	58.17	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	58.13	gold quality
body of stomach	UBERON:0001161	58.11	gold quality
right atrium auricular region	UBERON:0006631	57.86	gold quality
putamen	UBERON:0001874	56.78	gold quality
subcutaneous adipose tissue	UBERON:0002190	56.39	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• MiR-621-dependent FBXO11 suppression enhanced p53 activity and increased apoptosis in breast cancer cells exposed to chemotherapeutics.High expression level of miR-621 correlates with complete response and improves breast cancer disease free survival. (PMID:25867061)
• MiRNA-621 inhibits the malignant progression of non-small cell lung cancer via targeting SIX4. (PMID:31210312)
• LncRNA HOST2 enhances gefitinib-resistance in non-small cell lung cancer by down-regulating miRNA-621. (PMID:31799663)
• MiRNA-621 exerts tumor suppressor function in gastric adenocarcinoma by targeting AURKA/GSK-3beta pathway. (PMID:33629578)
• Hsa-circ_0000064 accelerates the malignant progression of gastric cancer via sponging microRNA-621. (PMID:34245111)
• MicroRNA-621 functions as a metastasis suppressor in colorectal cancer by directly targeting LEF1 and suppressing Wnt/beta-catenin signaling. (PMID:36087740)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.