MIR623

Summary

MIR623 (microRNA 623, HGNC:32879) is a microRNA gene on chromosome 13q32.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693208 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32879
Approved symbol	MIR623
Name	microRNA 623
Location	13q32.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-623
Ensembl gene	ENSG00000207719
Ensembl biotype	miRNA
Entrez	693208
RNAcentral	URS000075BF27 — miRNA, 98 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384986

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384986 — 1 exons

Exon	Start	End
ENSE00001499993	99356131	99356228

Expression profiles

Bgee: expression breadth broad, 99 present calls, max score 91.81.

Top tissues by expression

99 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
olfactory segment of nasal mucosa	UBERON:0005386	91.81	gold quality
bone marrow	UBERON:0002371	83.52	gold quality
adrenal tissue	UBERON:0018303	83.30	gold quality
blood	UBERON:0000178	82.33	gold quality
monocyte	CL:0000576	80.73	gold quality
gastrocnemius	UBERON:0001388	76.34	gold quality
skin of abdomen	UBERON:0001416	76.21	gold quality
calcaneal tendon	UBERON:0003701	75.63	gold quality
corpus callosum	UBERON:0002336	75.43	gold quality
liver	UBERON:0002107	75.27	gold quality
zone of skin	UBERON:0000014	74.67	gold quality
stomach	UBERON:0000945	74.60	gold quality
placenta	UBERON:0001987	74.58	gold quality
skin of leg	UBERON:0001511	73.68	gold quality
adult mammalian kidney	UBERON:0000082	73.51	gold quality
lymph node	UBERON:0000029	73.46	gold quality
islet of Langerhans	UBERON:0000006	73.38	gold quality
urinary bladder	UBERON:0001255	73.20	gold quality
left coronary artery	UBERON:0001626	73.01	gold quality
substantia nigra	UBERON:0002038	72.28	gold quality
pancreas	UBERON:0001264	72.27	gold quality
kidney	UBERON:0002113	72.23	gold quality
body of stomach	UBERON:0001161	72.00	gold quality
heart	UBERON:0000948	71.84	gold quality
fundus of stomach	UBERON:0001160	71.57	gold quality
subcutaneous adipose tissue	UBERON:0002190	71.49	gold quality
lower esophagus muscularis layer	UBERON:0035833	71.47	gold quality
body of pancreas	UBERON:0001150	71.44	gold quality
lower esophagus	UBERON:0013473	71.44	gold quality
esophagus	UBERON:0001043	71.11	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.60

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 7)

• our results suggest that miR-623 might function as a tumor suppressor in GC and could be a promising therapeutic target for patients with GC, especially those with chemotherapeutic resistance. (PMID:29495973)
• Study demonstrated that hsamiR623 binds to a specific sequence located within the 3’UTR of MMP1 and suppresses MMP1 expression. In addition, hsamiR623 suppressed the IL8induced expression of MMP1 and several EMT functional proteins, consequently inhibiting pancreatic cancer metastasis. (PMID:31115512)
• Overexpression of miR-623 suppresses progression of hepatocellular carcinoma via regulating the PI3K/Akt signaling pathway by targeting XRCC5. (PMID:31190447)
• miR-623 suppresses cell proliferation, migration and invasion through direct inhibition of XRCC5 in breast cancer. (PMID:32501811)
• HIF-1alpha-Mediated miR-623 Regulates Apoptosis and Inflammatory Responses of Nucleus Pulposus Induced by Oxidative Stress via Targeting TXNIP. (PMID:34394829)
• miR-515-3p, miR-623, miR-1272 and Notch3 protein as new biomarkers of Hepatocellular carcinoma. (PMID:34954928)
• MiR-623 links lncRNA RP11-89 and cyclin D1 to regulate the proliferation of glioblastoma cells. (PMID:36066507)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.