MIR624

Summary

MIR624 (microRNA 624, HGNC:32880) is a microRNA gene on chromosome 14q12.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693209 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32880
Approved symbol	MIR624
Name	microRNA 624
Location	14q12
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-624
Ensembl gene	ENSG00000207952
Ensembl biotype	miRNA
Entrez	693209
RNAcentral	URS00006A55B0 — miRNA, 97 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385217

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385217 — 1 exons

Exon	Start	End
ENSE00001500223	31014646	31014742

Expression profiles

Bgee: expression breadth broad, 76 present calls, max score 82.09.

Top tissues by expression

76 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney	UBERON:0002113	82.09	gold quality
endometrium	UBERON:0001295	81.42	gold quality
calcaneal tendon	UBERON:0003701	81.11	gold quality
liver	UBERON:0002107	78.20	gold quality
Brodmann (1909) area 9	UBERON:0013540	77.81	gold quality
adrenal tissue	UBERON:0018303	77.51	gold quality
monocyte	CL:0000576	76.60	gold quality
adult mammalian kidney	UBERON:0000082	76.32	gold quality
gastrocnemius	UBERON:0001388	76.16	gold quality
blood	UBERON:0000178	75.69	gold quality
stomach	UBERON:0000945	74.71	gold quality
right ovary	UBERON:0002118	74.01	gold quality
bone marrow	UBERON:0002371	73.27	gold quality
heart	UBERON:0000948	72.40	gold quality
corpus callosum	UBERON:0002336	71.30	gold quality
right adrenal gland cortex	UBERON:0035827	71.05	gold quality
left adrenal gland cortex	UBERON:0035825	70.73	gold quality
adrenal gland	UBERON:0002369	70.13	gold quality
body of pancreas	UBERON:0001150	70.01	gold quality
intestine	UBERON:0000160	69.95	gold quality
myometrium	UBERON:0001296	69.90	gold quality
lung	UBERON:0002048	69.76	gold quality
heart left ventricle	UBERON:0002084	69.32	gold quality
lower esophagus muscularis layer	UBERON:0035833	69.10	gold quality
body of stomach	UBERON:0001161	68.94	gold quality
substantia nigra	UBERON:0002038	68.56	gold quality
right lobe of liver	UBERON:0001114	68.53	gold quality
thoracic aorta	UBERON:0001515	68.43	gold quality
colon	UBERON:0001155	68.38	gold quality
left adrenal gland	UBERON:0001234	68.29	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.13

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 7)

• MiR340* and miR624* were confirmed to be upregulated in patients with Coronary artery disease as compared to healthy controls. (PMID:22022480)
• BDNF promoted tumor lymphangiogenesis by downregulating miR-624-3p in human chondrosarcoma tissues. (PMID:28771226)
• expression analysis of miRNAs from serum in osteosarcoma patients revealed differential expression of miR-215-5p and miR-642a-5p (PMID:29907935)
• Results showed that miR-624 expression was upregulated in osteosarcoma (OS) cells and tissues and suggest that it may be a negative regulator of PTPRB and a risk factor for tumor metastasis in OS progression. (PMID:31829261)
• MiR-624-5p enhances NLRP3 augmented gemcitabine resistance via EMT/IL-1beta/Wnt/beta-catenin signaling pathway in ovarian cancer. (PMID:35124344)
• Circ_0006404 enhances hepatocellular carcinoma progression by regulating miR-624. (PMID:35579835)
• Circulating RNA ZFR promotes hepatocellular carcinoma cell proliferation and epithelial-mesenchymal transition process through miR-624-3p/WEE1 axis. (PMID:37516591)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.