MIR625

Summary

MIR625 (microRNA 625, HGNC:32881) is a microRNA gene on chromosome 14q23.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693210 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32881
Approved symbol	MIR625
Name	microRNA 625
Location	14q23.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-625
Ensembl gene	ENSG00000207781
Ensembl biotype	miRNA
Entrez	693210
RNAcentral	URS0000001A7A — miRNA, 85 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385047

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385047 — 1 exons

Exon	Start	End
ENSE00001500054	65471102	65471186

Expression profiles

Bgee: expression breadth broad, 13 present calls, max score 79.63.

Top tissues by expression

13 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	79.63	gold quality
stomach	UBERON:0000945	78.68	gold quality
endometrium	UBERON:0001295	74.05	gold quality
right atrium auricular region	UBERON:0006631	73.56	gold quality
omental fat pad	UBERON:0010414	72.55	gold quality
calcaneal tendon	UBERON:0003701	72.09	gold quality
corpus callosum	UBERON:0002336	69.70	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.37	gold quality
skin of leg	UBERON:0001511	61.69	gold quality
minor salivary gland	UBERON:0001830	59.67	gold quality
colon	UBERON:0001155	54.16	gold quality
testis	UBERON:0000473	34.18	silver quality
left testis	UBERON:0004533	34.16	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.48

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• Increased circulating miR-625-3p is associated with malignant pleural mesothelioma. (PMID:22617246)
• miR-361-3p and miR-625* might have a protective influence on the development of non-small cell lung cancer. (PMID:22675530)
• Down-regulated miR-625 suppresses invasion and metastasis of gastric cancer by targeting ILK (PMID:22677169)
• High miR-625-3p levels were associated with resistance to oxaliplatin based chemotherapy and a shortened overall survival. (PMID:23506979)
• demonstrated that ectopic miR-625 expression inhibits the invasion and migration of HCT116 CRC cells both in vitro and in vivo (PMID:23861214)
• Low expression of miR-625 promotes cell proliferation and invasion in esophageal cancer cells. (PMID:24508466)
• miR-625 might function as an antimetastatic miRNA to have an important role in Hepatocellular carcinoma progression. (PMID:24632613)
• Our findings indicate the pivotal role of miR-625-3p in invasion of colorectal carcinoma (PMID:26314959)
• Serum levels of miR-627, miR-629 and miR-652 were significantly higher in gastric cancer patients than healthy controls. (PMID:26607322)
• miR-513a-5p, miR-22-3p and miR-625-5p may have an impact on the regulation of the immune response and inflammatory cytokine pathways through the regulation of their target gene(s), CBL, PPARGC1B and ESR1, which may then lead to a dust mite-induced asthma attack (PMID:27277384)
• Data show that miR-625-3p induces oxaliplatin resistance by abrogating MAP2K6-p38-regulated apoptosis and cell cycle control networks. (PMID:27526785)
• Data indicate that microRNA miR-625 targets the 3’ untranslated region (3’-UTR) of SRY-box 2 transcription factor SOX-2 (SOX2). (PMID:28129648)
• Results suggest further studies to identify the targets and function of microRNA miR-625-3p in CD8+ T-cells and to analyze its predictive value for an effective immune reconstitution. (PMID:28854245)
• There was a significant relationship between low miRNA-148a and miRNA-625-3p expression and tumor budding, which is thought to represent epithelial-mesenchymal transition. Both studied miRNAs may be associated with a more aggressive phenotype and could be the potential prognostic and predictive biomarkers in colorectal cancer (PMID:28863773)
• Bioinformatics analysis and luciferase reporter assays indicated that miR625 targeted the 3’untranslated region of Yesassociated protein 1 (YAP1). (PMID:29257207)
• MiR-625-3p promoted proliferation, migration and invasion of thyroid cancer cells by enhancing the expression of AEG-1. (PMID:29558717)
• Upregulated circular RNA circ_0007534 indicates an unfavorable prognosis in pancreatic ductal adenocarcinoma and regulates cell proliferation, apoptosis, and invasion by sponging miR-625 and miR-892b. (PMID:30382592)
• miR6255p may protect LPSinduced HBECs by targeting AKT2 and inhibiting the nuclear factorkappaB signaling pathway. Therefore, miR6255p may function as an inhibitor of asthma airway inflammation in HBECs by targeting AKT2. (PMID:30628701)
• MicroRNA-625-3p was highly expressed in oral squamous cell carcinoma (OSCC) tissues. OSCC patients with T3+T4 stage had higher expression of microRNA-625-3p than those with T1+T2 stage. SCAI was identified as a target gene of microRNA-625-3p. ROC curve showed that microRNA-625-3p and SCAI exert certain values in diagnosing OSCC. MicroRNA-625-3p promoted migration of OSCC cells, which was reversed by SCAI knockdown. (PMID:30720172)
• miR-625 and miR-920 are involved in the TGF-beta pathway; miR-625 but not miR920 is downregulated in patients with liver cirrhosis (PMID:30969085)
• circDENND2A is required for the hypoxia-induced malignancy of glioma cells and functions by sponging miR-625-5p. (PMID:30988674)
• CircRNA_0016418 expedites the progression of human skin melanoma via miR-625/YY1 axis. (PMID:31858560)
• Knockdown of lncRNA MIR503HG suppresses proliferation and promotes apoptosis of non-small cell lung cancer cells by regulating miR-489-3p and miR-625-5p. (PMID:31983569)
• Long noncoding RNA LINC00963 promotes breast cancer progression by functioning as a molecular sponge for microRNA-625 and thereby upregulating HMGA1. (PMID:32052688)
• MicroRNA-625-3p inhibits gastric cancer metastasis through modulating EZH2. (PMID:32096165)
• MicroRNA-625-5p Sponges lncRNA MALAT1 to Inhibit Cervical Carcinoma Cell Growth by Suppressing NF-kappaB Signaling. (PMID:32152961)
• The miR6253p/AXL axis induces nonT790M acquired resistance to EGFRTKI via activation of the TGFbeta/Smad pathway and EMT in EGFRmutant nonsmall cell lung cancer. (PMID:32319651)
• LncRNA LINC00909 promotes cell proliferation and metastasis in pediatric acute myeloid leukemia via miR-625-mediated modulation of Wnt/beta-catenin signaling. (PMID:32423818)
• LncRNA LINC00511 plays an oncogenic role in lung adenocarcinoma by regulating PKM2 expression via sponging miR-625-5p. (PMID:32716147)
• The enhancer activity of long interspersed nuclear element derived microRNA 625 induced by NF-kappaB. (PMID:33542430)
• Long noncoding RNA LINC01291 promotes the aggressive properties of melanoma by functioning as a competing endogenous RNA for microRNA-625-5p and subsequently increasing IGF-1R expression. (PMID:33674778)
• A functional SNP in miR-625-5p binding site of AKT2 3’UTR is associated with noise-induced hearing loss susceptibility in the Chinese population. (PMID:33768461)
• RBM24 exacerbates bladder cancer progression by forming a Runx1t1/TCF4/miR-625-5p feedback loop. (PMID:34021255)
• Long non-coding RNA LINC00511 regulates the expression of microRNA-625-5p and activates signal transducers and activators of transcription 3 (STAT3) to accelerate the progression of gastric cancer. (PMID:34224294)
• Circ-SNAP47 (hsa_circ_0016760) and miR-625-5p are regulators of WEE1 in regulation of chemoresistance, growth and invasion of DDP-tolerant NSCLC cells via ceRNA pathway. (PMID:34664776)
• MicroRNA-625-3p improved proliferation and involved chemotherapy resistance via targeting PTEN in high grade ovarian serous carcinoma. (PMID:35027053)
• Insights into the identification of a molecular signature for amyotrophic lateral sclerosis exploiting integrated microRNA profiling of iPSC-derived motor neurons and exosomes. (PMID:35286466)
• Hsa-miR-625 Upregulation Promotes Apoptosis in Acute Myeloid Leukemia Cell Line by Targeting Integrin-linked Kinase Pathway. (PMID:35485671)
• Functional roles of miR-625-5p and miR-874-3p in the progression of castration resistant prostate cancer. (PMID:35508255)
• Exosomal mir-625-3p derived from hypoxic lung cancer cells facilitates metastasis by targeting SCAI. (PMID:35988100)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.