MIR626

Summary

MIR626 (microRNA 626, HGNC:32882) is a microRNA gene on chromosome 15q15.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693211 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32882
Approved symbol	MIR626
Name	microRNA 626
Location	15q15.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-626
Ensembl gene	ENSG00000207766
Ensembl biotype	miRNA
Entrez	693211
RNAcentral	URS000071745D — miRNA, 94 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385032

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385032 — 1 exons

Exon	Start	End
ENSE00001500039	41691585	41691678

Expression profiles

Bgee: expression breadth broad, 59 present calls, max score 86.06.

Top tissues by expression

59 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney	UBERON:0002113	86.06	gold quality
adrenal tissue	UBERON:0018303	79.76	gold quality
endometrium	UBERON:0001295	79.61	gold quality
calcaneal tendon	UBERON:0003701	77.99	gold quality
blood	UBERON:0000178	77.61	gold quality
stomach	UBERON:0000945	76.13	gold quality
heart	UBERON:0000948	73.95	gold quality
monocyte	CL:0000576	73.79	gold quality
liver	UBERON:0002107	72.66	gold quality
lung	UBERON:0002048	72.34	gold quality
body of stomach	UBERON:0001161	72.19	gold quality
gastrocnemius	UBERON:0001388	71.92	gold quality
body of pancreas	UBERON:0001150	71.58	gold quality
intestine	UBERON:0000160	71.01	gold quality
tibial artery	UBERON:0007610	70.83	gold quality
ascending aorta	UBERON:0001496	70.10	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	70.10	gold quality
hypothalamus	UBERON:0001898	69.99	gold quality
heart left ventricle	UBERON:0002084	69.90	gold quality
thoracic aorta	UBERON:0001515	69.21	gold quality
body of uterus	UBERON:0009853	68.70	gold quality
esophagus mucosa	UBERON:0002469	67.02	gold quality
myometrium	UBERON:0001296	67.01	gold quality
right ovary	UBERON:0002118	66.85	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	66.84	gold quality
left adrenal gland	UBERON:0001234	66.80	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.70	gold quality
omental fat pad	UBERON:0010414	66.20	gold quality
putamen	UBERON:0001874	66.16	gold quality
left adrenal gland cortex	UBERON:0035825	66.13	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.46

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 7)

• Results found that miR-626 was up-regulated in bladder cancer (BC) cells and provided evidence that it promoted proliferation, migration and invasion of BC cells by targeting EYA4. (PMID:31101108)
• Low miR-626 expression is associated with age-related macular degeneration. (PMID:31446056)
• Our research suggests that hsa-miR-626 could be a potential biomarker for Parkinson’s disease diagnosis (PMID:31492481)
• Wnt/beta-catenin signaling pathway participates in the effect of miR-626 on oral squamous cell carcinoma by targeting RASSF4. (PMID:34121238)
• miR-626 Inhibition Enhanced the Radiosensitivity to Oral Squamous Cell Carcinoma via the Downregulation of Nuclear Factor Kappa-B Signaling. (PMID:35549438)
• Exosomal miR-626 promotes the malignant behavior of oral cancer cells by targeting NFIB. (PMID:35711020)
• MicroRNA-626 inhibits mTOR pathways activity of retinal pigment epithelial cells by targeting SLC7A5 in human ARPE-19 Cells. (PMID:37953589)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.