MIR627

Summary

MIR627 (microRNA 627, HGNC:32883) is a microRNA gene on chromosome 15q15.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693212 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32883
Approved symbol	MIR627
Name	microRNA 627
Location	15q15.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-627
Ensembl gene	ENSG00000207712
Ensembl biotype	miRNA
Entrez	693212
RNAcentral	URS00007599E2 — miRNA, 97 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384979

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384979 — 1 exons

Exon	Start	End
ENSE00001499986	42199570	42199666

Expression profiles

Bgee: expression breadth broad, 56 present calls, max score 88.37.

Top tissues by expression

56 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	88.37	gold quality
liver	UBERON:0002107	78.94	gold quality
blood	UBERON:0000178	76.72	gold quality
muscle of leg	UBERON:0001383	75.98	gold quality
calcaneal tendon	UBERON:0003701	75.95	gold quality
body of pancreas	UBERON:0001150	75.75	gold quality
endometrium	UBERON:0001295	74.56	gold quality
heart	UBERON:0000948	72.72	gold quality
left uterine tube	UBERON:0001303	72.24	gold quality
gastrocnemius	UBERON:0001388	72.05	gold quality
lung	UBERON:0002048	71.24	gold quality
tibial artery	UBERON:0007610	71.10	gold quality
right atrium auricular region	UBERON:0006631	70.32	gold quality
vagina	UBERON:0000996	70.31	gold quality
Brodmann (1909) area 9	UBERON:0013540	69.84	gold quality
corpus callosum	UBERON:0002336	69.57	gold quality
stomach	UBERON:0000945	68.98	gold quality
nucleus accumbens	UBERON:0001882	68.77	gold quality
right adrenal gland	UBERON:0001233	67.90	gold quality
ascending aorta	UBERON:0001496	67.87	gold quality
intestine	UBERON:0000160	67.82	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.59	gold quality
muscle layer of sigmoid colon	UBERON:0035805	67.34	gold quality
myometrium	UBERON:0001296	66.55	gold quality
left adrenal gland	UBERON:0001234	66.50	gold quality
transverse colon	UBERON:0001157	66.47	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.45	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.94	gold quality
adult mammalian kidney	UBERON:0000082	65.77	gold quality
skin of leg	UBERON:0001511	65.69	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.98

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 12)

• Serum levels of miR-627, miR-629 and miR-652 were significantly higher in gastric cancer patients than healthy controls. (PMID:26607322)
• This study demonstrated that the NR2C2-upstream open reading frame impaired the pivotal roles that UCA1-miR-627-5p-NR2C2 feedback loop had in regulating the malignancies of glioma cells by targeting NR2C2 directly. (PMID:30518750)
• miR-627 regulates TGF-beta1-induced NHLF proliferation and alpha-SMA and collagen I expression. miR-627 inhibits HMGB1 expression through direct targeting. (PMID:30536600)
• MicroRNA-627-5p inhibits the proliferation of hepatocellular carcinoma cells by targeting BCL3 transcription coactivator. (PMID:31793036)
• Association of rs2620381 polymorphism in miR-627 and gastric cancer. (PMID:31983284)
• RP11284F21.9 promotes lung carcinoma proliferation and invasion via the regulation of miR6273p/CCAR1. (PMID:32945522)
• The MIR155 host gene/microRNA-627/HMGB1/NF-kappaB loop modulates fibroblast proliferation and extracellular matrix deposition. (PMID:33482190)
• [Expression and effect of microRNA-627 in human hypertrophic scar]. (PMID:33887883)
• Human umbilical cord-derived mesenchymal stem cell-exosomal miR-627-5p ameliorates non-alcoholic fatty liver disease by repressing FTO expression. (PMID:34410623)
• Long non-coding RNA LBX2-AS1 predicts poor survival of colon cancer patients and promotes its progression via regulating miR-627-5p/RAC1/PI3K/AKT pathway. (PMID:35816228)
• Hsa_circ_0057104, by competitive adsorption of miR-627-5p, mediates CCND2 expression to promote malignant proliferation and Warburg effect of colorectal cancer. (PMID:37130193)
• Long noncoding RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the miR-627-3p/SPRED1 axis. (PMID:37434064)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.