MIR628

Summary

MIR628 (microRNA 628, HGNC:32884) is a microRNA gene on chromosome 15q21.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693213 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32884
Approved symbol	MIR628
Name	microRNA 628
Location	15q21.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-628
Ensembl gene	ENSG00000283891
Ensembl biotype	miRNA
Entrez	693213
RNAcentral	URS000050D31F — miRNA, 95 nt, 28 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385229

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385229 — 1 exons

Exon	Start	End
ENSE00001500235	55372940	55373034

Expression profiles

Bgee: expression breadth broad, 97 present calls, max score 87.73.

Top tissues by expression

97 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
olfactory segment of nasal mucosa	UBERON:0005386	87.73	gold quality
bone marrow	UBERON:0002371	86.07	gold quality
right hemisphere of cerebellum	UBERON:0014890	83.37	gold quality
skeletal muscle tissue	UBERON:0001134	82.88	gold quality
cerebellar hemisphere	UBERON:0002245	81.11	gold quality
Brodmann (1909) area 9	UBERON:0013540	79.98	gold quality
nucleus accumbens	UBERON:0001882	79.18	gold quality
right frontal lobe	UBERON:0002810	79.11	gold quality
frontal cortex	UBERON:0001870	78.98	gold quality
muscle of leg	UBERON:0001383	78.64	gold quality
gastrocnemius	UBERON:0001388	78.32	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	77.50	gold quality
blood	UBERON:0000178	77.28	gold quality
monocyte	CL:0000576	76.98	gold quality
prefrontal cortex	UBERON:0000451	76.98	gold quality
cerebral cortex	UBERON:0000956	76.87	gold quality
smooth muscle tissue	UBERON:0001135	76.86	gold quality
anterior cingulate cortex	UBERON:0009835	76.25	gold quality
brain	UBERON:0000955	75.84	gold quality
endometrium	UBERON:0001295	73.68	gold quality
islet of Langerhans	UBERON:0000006	73.37	gold quality
body of pancreas	UBERON:0001150	72.66	gold quality
caudate nucleus	UBERON:0001873	72.51	gold quality
right atrium auricular region	UBERON:0006631	72.44	gold quality
heart	UBERON:0000948	72.11	gold quality
amygdala	UBERON:0001876	72.05	gold quality
hypothalamus	UBERON:0001898	72.02	gold quality
urinary bladder	UBERON:0001255	71.99	gold quality
putamen	UBERON:0001874	71.93	gold quality
heart left ventricle	UBERON:0002084	71.86	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.27

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 24)

• Data indicate that expression of miR-1260, -26a, -335*, -576-3p, -628-3p and -664 were consistently dysregulated in both whole blood and H1N1 infected cells. (PMID:24116168)
• results demonstrate that the three miRNAs, particularly miR-628-5p, may be further developed as a biomarker, which can serve as novel noninvasive biomarker for prostate cancer diagnosis and prognosis (PMID:24477576)
• Low miR-628 expression is associated with chronic rejection in Bronchiolitis Obliterans Syndrome patients following lung transplantation. (PMID:25649290)
• High miR628 expression is associated with lung adenocarcinoma. (PMID:27036025)
• novel HLA-G-regulating miRs, miR-628-5p and miR-548q, were identified in renal cell carcinoma (PMID:27057628)
• Identify the circulating miRNA miR-628-5p as a novel potential biomarker of cardiac allograft vasculopathy in patients after orthotopic heart transplantation. (PMID:27653298)
• we established that miR-628-5p, a miRNA regulated by age and exercise, binds to the STARS 3’UTR to directly downregulate its transcription (PMID:27739650)
• the findings of this study provide evidence of the upregulation of miR628-3p in patients with atrophic non-union and that miR628-3p may exert an inhibitory effect on osteogenesis via the suppression of its target gene, RUNX2. (PMID:28035362)
• Besides, we found miR-628-5p targeted at and down-regulated the expression of fibroblast growth factor receptor 2 (FGFR2). FGFR2 expressed higher in ovarian cancer tissues and was correlated with worse prognosis. Our findings indicated that miR-628-5pplays an important role in ovarian cancer stem cell driven tumorigenesis. (PMID:29229394)
• We confirm that miR-628-3p promotes apoptosis and inhibits migration in A549 cells by negatively regulating HSP90. Our results may reveal a novel strategy for lung cancer treatment (PMID:29888262)
• miR-628-5p promotes growth and migration of osteosarcoma by targeting IFI44L. (PMID:31018104)
• MicroRNA-628-5p inhibits cell proliferation in glioma by targeting DDX59. (PMID:31111544)
• Circ-0001801 contributes to cell proliferation, migration, invasion and epithelial to mesenchymal transition (EMT) in glioblastoma by regulating miR-628-5p/HMGB3 axis. (PMID:31858556)
• MicroRNA-628-5p inhibits invasion and migration of human pancreatic ductal adenocarcinoma via suppression of the AKT/NF-kappa B pathway. (PMID:31957029)
• Salivary Small Extracellular Vesicles Associated miRNAs in Periodontal Status-A Pilot Study. (PMID:32316600)
• MicroRNA-628-5p Facilitates Enterovirus 71 Infection by Suppressing TRAF3 Signaling. (PMID:32398803)
• Deficiency of microRNA-628-5p promotes the progression of gastric cancer by upregulating PIN1. (PMID:32703934)
• Identification of regulatory mRNA and microRNA for differentiation into cementoblasts and periodontal ligament cells. (PMID:32797637)
• MiR-628-5p Inhibits Cervical Carcinoma Proliferation and Promotes Apoptosis by Targeting VEGF. (PMID:33775424)
• Regulation of innate immune response by miR-628-3p upregulated in the plasma of Stevens-Johnson syndrome patients. (PMID:34058393)
• AGAP2-AS1/miR-628-5p/FOXP2 feedback loop facilitates the growth of prostate cancer via activating WNT pathway. (PMID:34255057)
• Difference in the plasma level of miR-628-3p in atopic dermatitis patients with/without atopic keratoconjunctivitis. (PMID:34547828)
• A novel circular RNA circ_HN1/miR-628-5p/Ecto-5’-nucleotidase competing endogenous RNA network regulates gastric cancer development. (PMID:34637682)
• Exosomal miR-628-5p from M1 polarized macrophages hinders m6A modification of circFUT8 to suppress hepatocellular carcinoma progression. (PMID:36474147)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Gm56102	ENSMUSG00002075273
rattus_norvegicus	Mir628	ENSRNOG00000056387

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.