MIR631

Summary

MIR631 (microRNA 631, HGNC:32887) is a microRNA gene on chromosome 15q24.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693216 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32887
Approved symbol	MIR631
Name	microRNA 631
Location	15q24.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-631
Ensembl gene	ENSG00000284343
Ensembl biotype	miRNA
Entrez	693216
RNAcentral	URS000065B212 — miRNA, 75 nt, 8 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384904

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384904 — 1 exons

Exon	Start	End
ENSE00001499911	75353611	75353685

Expression profiles

Bgee: expression breadth broad, 13 present calls, max score 74.97.

Top tissues by expression

13 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adult mammalian kidney	UBERON:0000082	74.97	gold quality
blood	UBERON:0000178	74.83	gold quality
colon	UBERON:0001155	73.82	gold quality
monocyte	CL:0000576	71.36	gold quality
hypothalamus	UBERON:0001898	70.78	gold quality
placenta	UBERON:0001987	70.50	gold quality
smooth muscle tissue	UBERON:0001135	65.72	gold quality
ascending aorta	UBERON:0001496	63.10	gold quality
muscle of leg	UBERON:0001383	59.43	gold quality
gastrocnemius	UBERON:0001388	56.60	gold quality
heart left ventricle	UBERON:0002084	54.80	gold quality
tibial artery	UBERON:0007610	51.11	gold quality
skin of leg	UBERON:0001511	40.86	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• In all, our study demonstrates that miR-631 decreases PCa cell migration and invasion by dampening ZAP70 expression. (PMID:26620225)
• Low miR631 expression is associated with bortezomib-resistance in multiple myeloma. (PMID:28000886)
• Long noncoding RNA CCAT1 inhibits miR-613 to promote nonalcoholic fatty liver disease via increasing LXRalpha transcription. (PMID:32413192)
• MicroRNA-631 Resensitizes Doxorubicin-Resistant Chondrosarcoma Cells by Targeting Apelin. (PMID:36614283)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.