MIR632

Summary

MIR632 (microRNA 632, HGNC:32888) is a microRNA gene on chromosome 17q11.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693217 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32888
Approved symbol	MIR632
Name	microRNA 632
Location	17q11.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-632
Ensembl gene	ENSG00000283774
Ensembl biotype	miRNA
Entrez	693217
RNAcentral	URS00006AADFA — miRNA, 94 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385193

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385193 — 1 exons

Exon	Start	End
ENSE00001500199	32350109	32350202

Expression profiles

Bgee: expression breadth broad, 54 present calls, max score 96.28.

Top tissues by expression

54 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	96.28	gold quality
bone marrow	UBERON:0002371	81.49	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	81.40	gold quality
skeletal muscle tissue	UBERON:0001134	79.51	gold quality
duodenum	UBERON:0002114	78.80	gold quality
heart left ventricle	UBERON:0002084	77.55	gold quality
muscle of leg	UBERON:0001383	74.86	gold quality
gastrocnemius	UBERON:0001388	74.24	gold quality
right atrium auricular region	UBERON:0006631	72.84	gold quality
monocyte	CL:0000576	72.54	gold quality
islet of Langerhans	UBERON:0000006	71.27	gold quality
tibial nerve	UBERON:0001323	70.92	gold quality
blood	UBERON:0000178	69.56	gold quality
left lobe of thyroid gland	UBERON:0001120	69.22	gold quality
tibial artery	UBERON:0007610	69.10	gold quality
amygdala	UBERON:0001876	68.23	gold quality
right adrenal gland	UBERON:0001233	67.84	gold quality
left adrenal gland	UBERON:0001234	67.67	gold quality
transverse colon	UBERON:0001157	67.66	gold quality
lung	UBERON:0002048	67.63	gold quality
left adrenal gland cortex	UBERON:0035825	67.52	gold quality
omental fat pad	UBERON:0010414	66.78	gold quality
skin of leg	UBERON:0001511	66.61	gold quality
substantia nigra	UBERON:0002038	66.50	gold quality
ascending aorta	UBERON:0001496	65.65	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	65.62	gold quality
body of stomach	UBERON:0001161	65.34	gold quality
esophagus mucosa	UBERON:0002469	65.33	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.18	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	65.11	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.27

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 8)

• miR-632 is a potentially important epigenetic regulator of DNAJB6, which contributes to the downregulation of DNAJB6 and plays a supportive role in malignant progression (PMID:22710984)
• miR-632 Promotes Laryngeal Carcinoma Cell Proliferation, Migration, and Invasion Through Negative Regulation of GSK3beta. (PMID:29562960)
• Our study demonstrated that miR-632 promotes Gastric cancer progression by accelerating angiogenesis in a TFF1-dependent manner. Targeting of miR-632 may be a potential therapeutic approach for Gastric cancer patients. (PMID:30612555)
• TmiR-632 was upregulated and MYCT1 was downregulated in HCC. High miR-632 or low MYCT1 expression was shown as a predictor for poor overall survival of HCC patients. The study also found miR-632 was able to regulate HCC cell growth and invasion through targeting the expression of MYCT1. (PMID:30982352)
• Improved cardiovascular risk prediction in patients with end-stage renal disease on hemodialysis using machine learning modeling and circulating microribonucleic acids. (PMID:32754270)
• Long non-coding RNA FEZF1-AS1 promotes rectal cancer progression by competitively binding miR-632 with FAM83A. (PMID:35607960)
• miR-632 Induces DNAJB6 Inhibition Stimulating Endothelial-to-Mesenchymal Transition and Fibrosis in Marfan Syndrome Aortopathy. (PMID:37894814)
• Circ1811 suppresses gastric cancer progression by regulating the miR-632/DAPK1 axis. (PMID:38438055)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.