MIR633

Summary

MIR633 (microRNA 633, HGNC:32889) is a microRNA gene on chromosome 17q23.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693218 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32889
Approved symbol	MIR633
Name	microRNA 633
Location	17q23.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-633
Ensembl gene	ENSG00000207552
Ensembl biotype	miRNA
Entrez	693218
RNAcentral	URS0000678203 — miRNA, 98 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384821

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384821 — 1 exons

Exon	Start	End
ENSE00001499828	62944215	62944312

Expression profiles

Bgee: expression breadth broad, 37 present calls, max score 79.88.

Top tissues by expression

37 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	79.88	gold quality
blood	UBERON:0000178	77.24	gold quality
stomach	UBERON:0000945	76.95	gold quality
lower esophagus muscularis layer	UBERON:0035833	71.46	gold quality
body of pancreas	UBERON:0001150	70.72	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	70.52	gold quality
heart	UBERON:0000948	69.84	gold quality
thoracic aorta	UBERON:0001515	67.81	gold quality
esophagus mucosa	UBERON:0002469	67.57	gold quality
skin of leg	UBERON:0001511	67.14	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	66.94	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	66.28	gold quality
small intestine Peyer’s patch	UBERON:0003454	65.20	gold quality
Ammon’s horn	UBERON:0001954	65.06	gold quality
nucleus accumbens	UBERON:0001882	64.97	gold quality
muscle layer of sigmoid colon	UBERON:0035805	64.90	gold quality
putamen	UBERON:0001874	64.71	gold quality
corpus callosum	UBERON:0002336	64.57	gold quality
endocervix	UBERON:0000458	64.23	gold quality
caudate nucleus	UBERON:0001873	64.22	gold quality
skin of abdomen	UBERON:0001416	63.94	gold quality
right hemisphere of cerebellum	UBERON:0014890	63.27	gold quality
pituitary gland	UBERON:0000007	63.21	gold quality
thoracic mammary gland	UBERON:0005200	62.79	gold quality
tibial nerve	UBERON:0001323	62.48	gold quality
anterior cingulate cortex	UBERON:0009835	62.07	gold quality
lung	UBERON:0002048	61.77	gold quality
right frontal lobe	UBERON:0002810	61.65	gold quality
amygdala	UBERON:0001876	61.61	gold quality
Brodmann (1909) area 9	UBERON:0013540	59.92	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.98

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 7)

• miR-663 is down-regulated in K562, U937, Kasumi cell lines and CML patients. Over-expression of miR-663 can suppress the proliferation of K562 cells. (PMID:21518471)
• miR-663 may act as an oncogene in nasopharyngeal carcinoma. (PMID:22249270)
• Global miRNA profiling quantitatively confirms miR-922, miR-181c, and miR-633 are differentially regulated in patients with multiple sclerosis as compared with other diseases. (PMID:23077021)
• The overexpression of hypomethylated miR-663 induces chemotherapy resistance in human breast cancer cells by targeting heparin sulfate proteoglycan 2 (HSPG2). (PMID:23436656)
• MIR-663B expression levels in human follicular fluid samples were significantly negatively related to viable blastocyst formation and may become an objective evaluation criterion for embryo development potential after IVF. (PMID:29703434)
• our study revealed that miR-633/FADD axis played a significant role in the chemoresistance and Foxo3a regulated this pathway in gastric cancer (PMID:30628514)
• this study suggests that miR-633 deletion can activate the AKT/mTOR pathway by targeting AKT1 to participate in the pathogenesis of systemic lupus erythematosus. (PMID:30760089)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.