MIR634

Summary

MIR634 (microRNA 634, HGNC:32890) is a microRNA gene on chromosome 17q24.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693219 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32890
Approved symbol	MIR634
Name	microRNA 634
Location	17q24.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-634
Ensembl gene	ENSG00000207943
Ensembl biotype	miRNA
Entrez	693219
RNAcentral	URS000075DE74 — miRNA, 97 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385208

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385208 — 1 exons

Exon	Start	End
ENSE00001500214	66787072	66787168

Expression profiles

Bgee: expression breadth broad, 66 present calls, max score 75.47.

Top tissues by expression

66 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	75.47	gold quality
adult mammalian kidney	UBERON:0000082	74.53	gold quality
heart	UBERON:0000948	73.31	gold quality
bone marrow	UBERON:0002371	73.27	gold quality
right atrium auricular region	UBERON:0006631	73.26	gold quality
gastrocnemius	UBERON:0001388	72.82	gold quality
right adrenal gland cortex	UBERON:0035827	72.17	gold quality
islet of Langerhans	UBERON:0000006	72.06	gold quality
kidney	UBERON:0002113	70.73	gold quality
stomach	UBERON:0000945	70.44	gold quality
adrenal tissue	UBERON:0018303	70.38	gold quality
left adrenal gland cortex	UBERON:0035825	69.83	gold quality
left coronary artery	UBERON:0001626	69.52	gold quality
substantia nigra	UBERON:0002038	69.48	gold quality
endometrium	UBERON:0001295	69.37	gold quality
ascending aorta	UBERON:0001496	68.73	gold quality
left adrenal gland	UBERON:0001234	68.56	gold quality
body of stomach	UBERON:0001161	68.35	gold quality
tibial artery	UBERON:0007610	68.10	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.34	gold quality
liver	UBERON:0002107	67.01	gold quality
endocervix	UBERON:0000458	66.68	gold quality
skin of leg	UBERON:0001511	66.50	gold quality
body of uterus	UBERON:0009853	66.22	gold quality
Brodmann (1909) area 9	UBERON:0013540	66.13	gold quality
gall bladder	UBERON:0002110	65.57	gold quality
right ovary	UBERON:0002118	65.57	gold quality
tibial nerve	UBERON:0001323	65.49	gold quality
lung	UBERON:0002048	65.35	gold quality
right frontal lobe	UBERON:0002810	65.26	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.32

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 15)

• In xenograft mouse model, miR-634 inhibited tumor growth and enhanced paclitaxel sensitivity. (PMID:25400759)
• miR-634 mimics induced a proinflammatory phenotype in monocyte-derived macrophages, with enhanced expression and release of ADAM17 and IL-6 in Proteinase-3 ANCA-Associated Vasculitis (PMID:25788529)
• Overexpression of miR-634 activates the mitochondrial apoptotic pathway by direct concurrent targeting of genes associated with mitochondrial homeostasis, antiapoptosis, antioxidant ability, and autophagy. (PMID:26216549)
• by targeting mTOR signal pathway, miR-634 inhibited cell proliferation, migration and invasiveness in cervical cancer cells and the block of miR-634 enhances the mTOR expression at both the mRNA and protein levels which regulated the expression of mTOR negatively. (PMID:26367112)
• Findings indicate that 3’ utranslated regions (3’UTR) of PIK3R1, which encodes class I PI3K regulatory subunit 1 (alpha), contained the microRNA miR-634 seed sites sequences. (PMID:26972586)
• In clinical samples, the expression of Rab1A or DHX33 was reversely correlated with miR-634. Re-expression of Rab1A or DHX33 abrogated the miR-634-mediated inhibition of cell proliferation and migration. Collectively, our data suggest a tumor suppressor role of miR-634 in hepatocellular carcinoma. (PMID:27693040)
• MiR-634 is one of the few characterized examples of Pol-III-dependent intronic miRNAs. (PMID:28212793)
• he present study demonstrated that DANCR/miR-634/RAB1A axis plays crucial roles in the progression of glioma, and DANCR might potentially serve as a therapeutic target for the treatment of glioma patients. (PMID:29301870)
• The expression level of miR-634 in gastric cancer tissues and cell lines was lower than that in normal adjacent tissues and control cells. The survival of cells was decreased, and number of cells migrating and invading was decreased in the miR-634 mimics group. Over-expression of miR-634 inhibited the proliferation, migration, and invasion of gastric cancer cell lines. (PMID:29464926)
• This study showed that hsa_circ_0001742 could promote tongue squamous cell carcinoma progression by targeting miR-634/RAB1A pathway. (PMID:30944081)
• Downregulation of long non-coding RNA ZXF1 restricts cell survival by targeting miR-634-GRB2 in lung adenocarcinoma. (PMID:32160453)
• LncRNA SNHG8 promotes cell migration and invasion in breast cancer cell through miR-634/ZBTB20 axis. (PMID:33275231)
• Profiling of circular RNAs and circTPCN/miR-634/mTOR regulatory pathway in cervical cancer. (PMID:34029698)
• miR-634 inhibits human vascular smooth muscle cell proliferation and migration in hypertension through Wnt4/beta-catenin pathway. (PMID:34455769)
• Hsa_circ_0081069 facilitates tongue squamous cell carcinoma progression by modulating MAP2K4 expression via miR-634. (PMID:36181561)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.