MIR635

Summary

MIR635 (microRNA 635, HGNC:32891) is a microRNA gene on chromosome 17q24.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693220 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32891
Approved symbol	MIR635
Name	microRNA 635
Location	17q24.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-635
Ensembl gene	ENSG00000207561
Ensembl biotype	miRNA
Entrez	693220
RNAcentral	URS000075CD0C — miRNA, 98 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384830

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384830 — 1 exons

Exon	Start	End
ENSE00001499837	68424451	68424548

Expression profiles

Bgee: expression breadth ubiquitous, 115 present calls, max score 93.51.

Top tissues by expression

115 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
placenta	UBERON:0001987	93.51	gold quality
rectum	UBERON:0001052	93.40	gold quality
monocyte	CL:0000576	93.39	gold quality
endometrium	UBERON:0001295	93.22	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	92.87	gold quality
apex of heart	UBERON:0002098	92.68	gold quality
right hemisphere of cerebellum	UBERON:0014890	92.63	gold quality
heart left ventricle	UBERON:0002084	92.60	gold quality
minor salivary gland	UBERON:0001830	92.51	gold quality
blood	UBERON:0000178	92.38	gold quality
body of stomach	UBERON:0001161	92.26	gold quality
saliva-secreting gland	UBERON:0001044	92.14	gold quality
granulocyte	CL:0000094	92.01	gold quality
mucosa of stomach	UBERON:0001199	91.97	gold quality
heart	UBERON:0000948	91.88	gold quality
pituitary gland	UBERON:0000007	91.74	gold quality
transverse colon	UBERON:0001157	91.70	gold quality
stomach	UBERON:0000945	91.63	gold quality
adrenal tissue	UBERON:0018303	91.55	gold quality
adenohypophysis	UBERON:0002196	91.42	gold quality
right atrium auricular region	UBERON:0006631	91.39	gold quality
cerebellar hemisphere	UBERON:0002245	91.33	gold quality
smooth muscle tissue	UBERON:0001135	91.11	gold quality
left adrenal gland	UBERON:0001234	90.96	gold quality
right adrenal gland	UBERON:0001233	90.95	gold quality
left adrenal gland cortex	UBERON:0035825	90.94	gold quality
right adrenal gland cortex	UBERON:0035827	90.80	gold quality
adrenal gland	UBERON:0002369	90.63	gold quality
right coronary artery	UBERON:0001625	90.53	gold quality
tibial nerve	UBERON:0001323	90.50	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.45

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• These results have suggested a novel tumor suppressive role for miR-635 in non-small cell lung cancer. (PMID:27810784)
• miR-635 targets KIFC1 to inhibit the progression of gastric cancer. (PMID:32753405)
• Circ_0000735 enhances the proliferation, metastasis and glycolysis of non-small cell lung cancer by regulating the miR-635/FAM83F axis. (PMID:33560141)
• Long noncoding RNADUXAP8 regulates TOP2A in the growth and metastasis of osteosarcoma via microRNA635. (PMID:33982765)
• Circ_0102231 inactivates the PI3K/AKT signaling pathway by regulating the miR-635/NOVA2 pathway to promote the progression of non-small cell lung cancer. (PMID:37864285)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.