MIR636

Summary

MIR636 (microRNA 636, HGNC:32892) is a microRNA gene on chromosome 17q25.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693221 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32892
Approved symbol	MIR636
Name	microRNA 636
Location	17q25.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-636
Ensembl gene	ENSG00000283805
Ensembl biotype	miRNA
Entrez	693221
RNAcentral	URS000062E57E — miRNA, 99 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384825

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384825 — 1 exons

Exon	Start	End
ENSE00001499832	76736450	76736548

Expression profiles

Bgee: expression breadth tissue_specific, 3 present calls, max score 78.38.

Top tissues by expression

3 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adipose tissue	UBERON:0001013	78.38	gold quality
blood	UBERON:0000178	76.60	gold quality
heart	UBERON:0000948	72.98	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 9)

• miR-636 might function as a tumor suppressor miRNA affecting hepatocellular carcinoma (HCC) tumorigenesis via downregulation of Ras, and that ANT2 suppression by shRNA could exert an anticancer effect by restoring miR-636 expression in HCC. (PMID:23306701)
• miR-636: A Newly-Identified Actor for the Regulation of Pulmonary Inflammation in Cystic Fibrosis. (PMID:31803183)
• CircPTPRA acts as a tumor suppressor in bladder cancer by sponging miR-636 and upregulating KLF9. (PMID:31821171)
• miR-636 represses cell survival by targeting CDK6/Bcl-2 in cervical cancer. (PMID:31889428)
• Identifying the key genes and microRNAs in prostate cancer bone metastasis by bioinformatics analysis. (PMID:32027093)
• Downregulation of circRNA_100876 Inhibited Progression of NSCLC In Vitro via Targeting miR-636. (PMID:33030101)
• CircRNA-PTPRA promoted the progression of atherosclerosis through sponging with miR-636 and upregulating the transcription factor SP1. (PMID:33336764)
• Circ_0025039 acts an oncogenic role in the progression of non-small cell lung cancer through miR-636-dependent regulation of CORO1C. (PMID:35034254)
• Circ_0010235 facilitates lung cancer development and immune escape by regulating miR-636/PDL1 axis. (PMID:35167195)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.