MIR637

Summary

MIR637 (microRNA 637, HGNC:32893) is a microRNA gene on chromosome 19p13.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693222 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32893
Approved symbol	MIR637
Name	microRNA 637
Location	19p13.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-637
Ensembl gene	ENSG00000283928
Ensembl biotype	miRNA
Entrez	693222
RNAcentral	URS000075AC40 — miRNA, 99 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385000

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385000 — 1 exons

Exon	Start	End
ENSE00001500007	3961414	3961512

Expression profiles

Bgee: expression breadth broad, 52 present calls, max score 75.31.

Top tissues by expression

52 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	75.31	gold quality
endometrium	UBERON:0001295	75.02	gold quality
muscle layer of sigmoid colon	UBERON:0035805	74.70	gold quality
blood	UBERON:0000178	73.98	gold quality
heart left ventricle	UBERON:0002084	72.78	gold quality
islet of Langerhans	UBERON:0000006	70.99	gold quality
heart	UBERON:0000948	70.61	gold quality
lymph node	UBERON:0000029	70.10	gold quality
right frontal lobe	UBERON:0002810	68.19	gold quality
lung	UBERON:0002048	67.56	gold quality
right atrium auricular region	UBERON:0006631	66.66	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.55	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.52	gold quality
anterior cingulate cortex	UBERON:0009835	65.60	gold quality
skin of leg	UBERON:0001511	65.44	gold quality
minor salivary gland	UBERON:0001830	64.99	gold quality
adipose tissue	UBERON:0001013	64.92	gold quality
gastrocnemius	UBERON:0001388	64.56	gold quality
frontal cortex	UBERON:0001870	64.16	gold quality
transverse colon	UBERON:0001157	63.99	gold quality
cerebral cortex	UBERON:0000956	61.38	gold quality
zone of skin	UBERON:0000014	61.30	gold quality
Ammon’s horn	UBERON:0001954	61.21	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	60.71	gold quality
stomach	UBERON:0000945	60.51	gold quality
tibial nerve	UBERON:0001323	60.31	gold quality
body of stomach	UBERON:0001161	60.01	gold quality
omental fat pad	UBERON:0010414	59.24	gold quality
hypothalamus	UBERON:0001898	58.88	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	58.80	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 38)

• miR-637 suppresses the constitutive activation of Stat3 by targeting autocrine LIF in human HCC. Furthermore, this suppressive effect is important for the growth of hepatocellular carcinoma cells in vitro and for the development of liver cancer in vivo. (PMID:21809363)
• the expression of miR-637 was indispensable for maintaining the balance of adipocytes and osteoblasts (PMID:21880893)
• Analysis of two potential targets for miR-637 and miR-1228 in HOB, type IV collagen (COL4A1) and bone morphogenic protein 2 kinase (BMP2K), respectively, showed that 1,25D-mediates suppression of these targets via distinct mechanisms (PMID:23362149)
• Suppressed expression of miR-637 and increased Akt1 protein levels were correlated with unfavorable progression and poor prognosis, respectively, and a negative relationship between the miR-637 expression and Akt1 protein levels was observed in gliomas (PMID:25597410)
• microRNA 637 potently inhibited C-reactive protein expression in competition with HuR (PMID:26438598)
• Our study proved that the CDK6 gene is a target of miR-637, and demonstrated the regulatory association between miR-637 and CDK6 (PMID:27794186)
• that Akt1 was a novel target for miR-637, and its knockdown also induced cell growth inhibition and apoptosis in pancreatic ductal adenocarcinoma cells (PMID:29366808)
• Low miR637 expression is associated with papillary thyroid carcinoma cell proliferation, invasion and migration. (PMID:29474928)
• Downregulation of miR-637 promotes proliferation and migration of fibroblasts by targeting Smad3 in keloids. (PMID:29845237)
• FAL1 may work as a ceRNA to modulate AKT1 expression via competitively binding to miR-637 in HSCR. (PMID:30062828)
• Study demonstrates that miR-637 inhibites melanoma cell proliferation by activation of AKT signaling pathway and induces apoptosis through regulation of Bcl-2/Bax expression via targeting P-REX2a. (PMID:30213289)
• lncRNA FAL1 promotes carcinogenesis of CRC cells via regulation of the miR-637/NUPR1 pathway. (PMID:30267804)
• LncRNA C5orf66-AS1, as a competitive endogenous RNA, regulated the effect of RING1 on the proliferation, apoptosis and cell cycle of cervical cancer cells through adsorbing miR-637. (PMID:30518760)
• MiR-637 inhibits proliferation and invasion of hepatoma cells by targeted degradation of AKT1. (PMID:30720164)
• Circular RNA (hsa_circ_0051240) promotes cell proliferation, migration and invasion in ovarian cancer through miR-637/KLK4 axis (PMID:30945557)
• circ-NOTCH1 acts as a sponge of miR-637 and affects the expression of its target gene Apelin to regulate gastric cancer cell growth. (PMID:31276627)
• LINC00473 could act as a ceRNA of miR-637 to promote glioma progression through regulating CDK6 expression (PMID:31561732)
• Mechanistic investigation elucidated that LINC01234 inhibited the activity of miR-637 to increase the expression of NUPR1; this contributed to malignant behaviors of oral squamous cell carcinoma cells. (PMID:31590125)
• circHIPK3 promotes OXA resistance in CRC by sponging miR-637, which is dependent on the inhibition of autophagy-related cell death via STAT3/Bcl-2/beclin1 signalling pathway. (PMID:31631038)
• MicroRNA-637 is upregulated in postmenopausal osteoporosis patients. (PMID:32151564)
• Downregulation of miR-637 promotes vascular smooth muscle cell proliferation and migration via regulation of insulin-like growth factor-2. (PMID:32399056)
• Circ_PSD3 promotes the progression of papillary thyroid carcinoma via the miR-637/HEMGN axis. (PMID:33203523)
• The microarray identification circular RNA hsa_circ_0105015 up-regulated involving inflammation pathway in essential hypertension. (PMID:33236350)
• Diagnostic value of miR-637 in patients with atherosclerosis and its predictive significance for the future cardiovascular events. (PMID:33283668)
• microRNA-637 promotes apoptosis and suppresses proliferation and autophagy in multiple myeloma cell lines via NUPR1. (PMID:33332746)
• circHIPK3 promotes proliferation and migration and invasion via regulation of miR637/HDAC4 signaling in osteosarcoma cells. (PMID:33416147)
• Dysregulation of miR-637 Is Involved in the Development of Retinopathy in Hypertension Patients and Serves a Regulatory Role in Retinol Endothelial Cell Proliferation. (PMID:33530086)
• The function of miR-637 in non-small cell lung cancer progression and prognosis. (PMID:34176781)
• A circular RNA, circUSP36, accelerates endothelial cell dysfunction in atherosclerosis by adsorbing miR-637 to enhance WNT4 expression. (PMID:34519627)
• Dysregulation of miR-637 serves as a diagnostic biomarker in patients with carotid artery stenosis and predicts the occurrence of the cerebral ischemic event. (PMID:34606407)
• CircLDLR Promotes Papillary Thyroid Carcinoma Tumorigenicity by Regulating miR-637/LMO4 Axis. (PMID:34925640)
• Circular RNA circ_UBAP2 facilitates the progression of osteosarcoma by regulating microRNA miR-637/high-mobility group box (HMGB) 2 axis. (PMID:35114890)
• miR-637 Inhibits Osteogenic Differentiation of Human Intervertebral Disc Cartilage Endplate Stem Cells by Targeting WNT5A. (PMID:35296211)
• Circ_0017274 acts on miR-637/CDX2 axis to facilitate cisplatin resistance in gastric cancer. (PMID:35748299)
• Knockdown of circ_0002194 protects against oxidized low-density lipoprotein-induced cell damage via the regulation of the miR-637/PACS2 axis in human vascular endothelial cells. (PMID:35951762)
• Circ_SNX27 regulates hepatocellular carcinoma development via miR-637/FGFR1 axis. (PMID:36029209)
• Investigation of miR-133a, miR-637 and miR-944 genes expression and their relationship with PI3K/AKT signaling in women with breast cancer. (PMID:36656380)
• A novel axis of circKIF4A-miR-637-STAT3 promotes brain metastasis in triple-negative breast cancer. (PMID:38029538)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.