MIR639

Summary

MIR639 (microRNA 639, HGNC:32895) is a microRNA gene on chromosome 19p13.12.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693224 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32895
Approved symbol	MIR639
Name	microRNA 639
Location	19p13.12
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-639
Ensembl gene	ENSG00000283822
Ensembl biotype	miRNA
Entrez	693224
RNAcentral	URS00006BE831 — miRNA, 98 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384974

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384974 — 1 exons

Exon	Start	End
ENSE00001499981	14529543	14529640

Expression profiles

Bgee: expression breadth broad, 65 present calls, max score 86.62.

Top tissues by expression

65 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	86.62	gold quality
prefrontal cortex	UBERON:0000451	76.12	gold quality
islet of Langerhans	UBERON:0000006	76.11	gold quality
gastrocnemius	UBERON:0001388	73.48	gold quality
blood	UBERON:0000178	72.29	gold quality
body of pancreas	UBERON:0001150	68.14	gold quality
monocyte	CL:0000576	67.89	gold quality
stomach	UBERON:0000945	67.88	gold quality
muscle layer of sigmoid colon	UBERON:0035805	67.80	gold quality
endometrium	UBERON:0001295	67.44	gold quality
right atrium auricular region	UBERON:0006631	67.41	gold quality
vagina	UBERON:0000996	67.31	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	67.15	gold quality
skin of abdomen	UBERON:0001416	66.61	gold quality
ascending aorta	UBERON:0001496	66.60	gold quality
heart left ventricle	UBERON:0002084	66.59	gold quality
heart	UBERON:0000948	66.16	gold quality
Brodmann (1909) area 9	UBERON:0013540	66.01	gold quality
body of stomach	UBERON:0001161	65.72	gold quality
omental fat pad	UBERON:0010414	65.05	gold quality
esophagus mucosa	UBERON:0002469	64.54	gold quality
lower esophagus muscularis layer	UBERON:0035833	63.70	gold quality
myometrium	UBERON:0001296	63.51	gold quality
adipose tissue	UBERON:0001013	63.37	gold quality
right adrenal gland cortex	UBERON:0035827	63.36	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	63.33	gold quality
right lobe of thyroid gland	UBERON:0001119	63.15	gold quality
right adrenal gland	UBERON:0001233	62.73	gold quality
subcutaneous adipose tissue	UBERON:0002190	62.37	gold quality
left ovary	UBERON:0002119	61.85	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• suggest that reduced expression of miR-639 underscores the mechanism of TGFbeta-induced epithelial-mesenchymal transition in tongue squamous cell carcinoma by targeting FOXC1 and may serve as therapeutic targets in the process of metastasis (PMID:25130698)
• miR-639 upregulation was associated with development of thyroid carcinoma, promoting cell proliferation and cell cycle by targeting CDKN1A. (PMID:27829546)
• MicroRNA-639 is Down-Regulated in Hepatocellular Carcinoma Tumor Tissue and Inhibits Proliferation and Migration of Human Hepatocellular Carcinoma Cells Through the KAT7/Wnt/beta-Catenin Pathway. (PMID:31955177)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.