MIR640

Summary

MIR640 (microRNA 640, HGNC:32896) is a microRNA gene on chromosome 19p13.11.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693225 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32896
Approved symbol	MIR640
Name	microRNA 640
Location	19p13.11
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-640
Ensembl gene	ENSG00000207821
Ensembl biotype	miRNA
Entrez	693225
RNAcentral	URS0000666A9B — miRNA, 96 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385086

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385086 — 1 exons

Exon	Start	End
ENSE00001500092	19435063	19435158

Expression profiles

Bgee: expression breadth broad, 60 present calls, max score 95.42.

Top tissues by expression

60 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	95.42	gold quality
kidney	UBERON:0002113	85.14	gold quality
blood	UBERON:0000178	82.38	gold quality
liver	UBERON:0002107	79.34	gold quality
adrenal tissue	UBERON:0018303	78.52	gold quality
gastrocnemius	UBERON:0001388	75.34	gold quality
stomach	UBERON:0000945	73.05	gold quality
lung	UBERON:0002048	72.83	gold quality
monocyte	CL:0000576	72.37	gold quality
body of pancreas	UBERON:0001150	72.29	gold quality
right adrenal gland cortex	UBERON:0035827	71.74	gold quality
heart	UBERON:0000948	71.27	gold quality
calcaneal tendon	UBERON:0003701	70.56	gold quality
lower esophagus muscularis layer	UBERON:0035833	70.31	gold quality
tibial artery	UBERON:0007610	70.00	gold quality
hypothalamus	UBERON:0001898	69.89	gold quality
myometrium	UBERON:0001296	69.05	gold quality
left adrenal gland cortex	UBERON:0035825	68.68	gold quality
intestine	UBERON:0000160	68.59	gold quality
ascending aorta	UBERON:0001496	68.11	gold quality
left adrenal gland	UBERON:0001234	67.95	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.75	gold quality
body of stomach	UBERON:0001161	67.73	gold quality
right lobe of liver	UBERON:0001114	67.69	gold quality
transverse colon	UBERON:0001157	67.16	gold quality
subcutaneous adipose tissue	UBERON:0002190	67.13	gold quality
tibial nerve	UBERON:0001323	67.08	gold quality
endometrium	UBERON:0001295	66.82	gold quality
esophagus mucosa	UBERON:0002469	66.40	gold quality
colon	UBERON:0001155	66.25	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.32

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• Hydrogen sulfide promotes angiogenesis by downregulating miR-640 and increasing the levels of HIF1A through the VEGFR2-mTOR pathway. (PMID:26879375)
• MiR-640 inhibited the expression of beta-catenin and EP300, therefore, restrained WNT signal and induced the degeneration in nucleus pulposus cells. miR-640 inhibitor treatment exhibited the effects of anti-inflammation, reverse WNT signalling pathway exhaustion, and remission of degenerative characteristics in vitro. (PMID:31343104)
• Roles of miR-640 and Zinc Finger Protein 91 (ZFP91) in Angiopoietin-1-Induced In Vitro Angiogenesis. (PMID:32630670)
• Silencing circular RNA circ_0054537 and upregulating microRNA-640 suppress malignant progression of renal cell carcinoma via regulating neuronal pentraxin-2 (NPTX2). (PMID:34565284)
• Micro RNA-640 Targeting SLIT1 Enhances Glioma Radiosensitivity by Restraining the Activation of Wnt/beta-Catenin Signaling Pathway. (PMID:35996510)
• Regulatory mechanism of DDX5 in ox-LDL-induced endothelial cell injury through the miR-640/SOX6 axis. (PMID:39093065)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.