MIR642A

Summary

MIR642A (microRNA 642a, HGNC:32898) is a microRNA gene on chromosome 19q13.32.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693227 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32898
Approved symbol	MIR642A
Name	microRNA 642a
Location	19q13.32
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-642
Ensembl gene	ENSG00000207773
Ensembl biotype	miRNA
Entrez	693227
RNAcentral	URS000069A81A — miRNA, 97 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385039

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385039 — 1 exons

Exon	Start	End
ENSE00001500046	45674928	45675024

Expression profiles

Bgee: expression breadth broad, 85 present calls, max score 96.58.

Top tissues by expression

85 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right uterine tube	UBERON:0001302	96.58	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	93.11	gold quality
body of stomach	UBERON:0001161	84.37	gold quality
stomach	UBERON:0000945	83.48	gold quality
adrenal tissue	UBERON:0018303	81.68	gold quality
fallopian tube	UBERON:0003889	80.17	gold quality
transverse colon	UBERON:0001157	79.65	gold quality
colon	UBERON:0001155	77.99	gold quality
pancreas	UBERON:0001264	76.78	gold quality
body of pancreas	UBERON:0001150	76.75	gold quality
islet of Langerhans	UBERON:0000006	76.08	gold quality
right atrium auricular region	UBERON:0006631	75.80	gold quality
blood	UBERON:0000178	75.29	gold quality
saliva-secreting gland	UBERON:0001044	75.15	gold quality
minor salivary gland	UBERON:0001830	75.12	gold quality
lower esophagus mucosa	UBERON:0035834	74.61	gold quality
fundus of stomach	UBERON:0001160	74.35	gold quality
heart	UBERON:0000948	74.28	gold quality
ectocervix	UBERON:0012249	73.56	gold quality
endocervix	UBERON:0000458	73.54	gold quality
urinary bladder	UBERON:0001255	72.98	gold quality
omental fat pad	UBERON:0010414	72.81	gold quality
lymph node	UBERON:0000029	72.77	gold quality
subcutaneous adipose tissue	UBERON:0002190	72.65	gold quality
muscle of leg	UBERON:0001383	72.54	gold quality
rectum	UBERON:0001052	72.46	gold quality
heart left ventricle	UBERON:0002084	72.20	gold quality
gastrocnemius	UBERON:0001388	71.86	gold quality
vagina	UBERON:0000996	71.66	gold quality
thoracic mammary gland	UBERON:0005200	71.50	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.93

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 8)

• The un-annotated miR-642a-3p is a highly adipocyte-specific miRNA. (PMID:21767385)
• Data indicate that three miRs (miR-484, -642, and -217) were able to predict chemoresistance and vasculature of serous epithelial ovarian carcinomas through the regulation of the VEGFB and VEGFR2 pathways (PMID:23697367)
• MiR-642 regulates Linc00974 and KRT19 interaction determining tumor cell proliferation and metastasis in hepatocellular carcinoma. (PMID:25476897)
• High miR642 expression is associated with ulcerative colitis as compared to Crohn’s colitis. (PMID:29272478)
• miR-642a-5p partially mediates the effects of lipopolysaccharide on human pulmonary microvascular endothelial cells via eEF2. (PMID:32881411)
• Down-regulation of lncRNA PCGEM1 inhibits cervical carcinoma by modulating the miR-642a-5p/LGMN axis. (PMID:33121976)
• Knockdown of lncRNA LUCAT1 attenuates sepsisinduced myocardial cell injury by sponging miR-642a. (PMID:34272987)
• The tumor suppressor miR-642a-5p targets Wilms Tumor 1 gene and cell-cycle progression in prostate cancer. (PMID:34504167)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.