MIR642B

Summary

MIR642B (microRNA 642b, HGNC:38902) is a microRNA gene on chromosome 19q13.32.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500845 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38902
Approved symbol	MIR642B
Name	microRNA 642b
Location	19q13.32
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-642b
Ensembl gene	ENSG00000283212
Ensembl biotype	miRNA
Entrez	100500845
RNAcentral	URS000075E432 — miRNA, 77 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000637346

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000637346 — 1 exons

Exon	Start	End
ENSE00003800998	45674932	45675008

Expression profiles

Bgee: expression breadth tissue_specific, 5 present calls, max score 68.64.

Top tissues by expression

5 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
heart left ventricle	UBERON:0002084	68.64	gold quality
omental fat pad	UBERON:0010414	65.22	gold quality
nucleus accumbens	UBERON:0001882	62.66	gold quality
hypothalamus	UBERON:0001898	56.78	gold quality
left lobe of thyroid gland	UBERON:0001120	49.98	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• This study using microarray technology found two miRNAs including has-miR-4717-5p and has-miR-642b-5p were upregulated in patients with Guillain-Barre syndrome. (PMID:27836180)
• Our findings showed that PRRX1 may be one of the main driving forces for the cellular phenotype plasticity and tumor dormancy of HNSCC. Therefore, we can raise the possibility that EMT may help to keep cancer cell in dormant state and mesenchymal-epithelial transition may resurge dormancy in HNSCC. (PMID:30622052)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.