MIR643

Summary

MIR643 (microRNA 643, HGNC:32899) is a microRNA gene on chromosome 19q13.41.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693228 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32899
Approved symbol	MIR643
Name	microRNA 643
Location	19q13.41
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-643
Ensembl gene	ENSG00000208002
Ensembl biotype	miRNA
Entrez	693228
RNAcentral	URS00006D5889 — miRNA, 97 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385267

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385267 — 1 exons

Exon	Start	End
ENSE00001500273	52281797	52281893

Expression profiles

Bgee: expression breadth broad, 98 present calls, max score 87.81.

Top tissues by expression

98 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	87.81	gold quality
endometrium	UBERON:0001295	82.30	gold quality
calcaneal tendon	UBERON:0003701	77.94	gold quality
bone marrow	UBERON:0002371	77.37	gold quality
monocyte	CL:0000576	77.20	gold quality
vermiform appendix	UBERON:0001154	76.95	gold quality
granulocyte	CL:0000094	76.82	gold quality
adrenal tissue	UBERON:0018303	76.69	gold quality
corpus callosum	UBERON:0002336	76.56	gold quality
blood	UBERON:0000178	76.35	gold quality
islet of Langerhans	UBERON:0000006	75.36	gold quality
muscle of leg	UBERON:0001383	73.93	gold quality
placenta	UBERON:0001987	73.88	gold quality
adult mammalian kidney	UBERON:0000082	73.78	gold quality
stomach	UBERON:0000945	72.83	gold quality
right adrenal gland	UBERON:0001233	72.61	gold quality
adrenal gland	UBERON:0002369	72.57	gold quality
gastrocnemius	UBERON:0001388	72.52	gold quality
body of stomach	UBERON:0001161	72.14	gold quality
kidney	UBERON:0002113	72.01	gold quality
right adrenal gland cortex	UBERON:0035827	71.95	gold quality
left adrenal gland	UBERON:0001234	71.68	gold quality
body of pancreas	UBERON:0001150	71.49	gold quality
urinary bladder	UBERON:0001255	71.45	gold quality
left coronary artery	UBERON:0001626	71.25	gold quality
heart	UBERON:0000948	71.19	gold quality
prefrontal cortex	UBERON:0000451	71.04	gold quality
right atrium auricular region	UBERON:0006631	70.99	gold quality
heart left ventricle	UBERON:0002084	70.68	gold quality
ascending aorta	UBERON:0001496	70.66	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.48

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• In summary, the authors provide novel lines of evidence suggesting that early-branched eukaryote Entamoeba histolytica may promote apoptosis of human colon cells by modulating, in part, the host microRNome which highlight an unexpected role for miRNA-643/XIAP axis in the host cellular response to parasites infection. (PMID:30671387)
• MiR-643 inhibits lipopolysaccharide-induced endometritis progression by targeting TRAF6. (PMID:31930635)
• MiR-643 Functions as a Potential Tumor Suppressor in Gastric Cancer by Inhibiting Cell Proliferation and Invasion via Targeting TXNDC9. (PMID:34452887)
• CircRNA circFADS2 is Downregulated in Endometritis and its Overexpression Promotes miR-643 Maturation in Human Endometrial Epithelial Cells to Suppress Cell Apoptosis. (PMID:34478121)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.