MIR644A

Summary

MIR644A (microRNA 644a, HGNC:32900) is a microRNA gene on chromosome 20q11.22.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693229 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32900
Approved symbol	MIR644A
Name	microRNA 644a
Location	20q11.22
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-644
Ensembl gene	ENSG00000207997
Ensembl biotype	miRNA
Entrez	693229
RNAcentral	URS000067B227 — miRNA, 94 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385262

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385262 — 1 exons

Exon	Start	End
ENSE00001500268	34466325	34466418

Expression profiles

Bgee: expression breadth broad, 91 present calls, max score 99.13.

Top tissues by expression

91 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	99.13	gold quality
corpus callosum	UBERON:0002336	91.44	gold quality
calcaneal tendon	UBERON:0003701	88.89	gold quality
sural nerve	UBERON:0015488	86.10	gold quality
adrenal tissue	UBERON:0018303	84.83	gold quality
bone marrow	UBERON:0002371	84.69	gold quality
kidney	UBERON:0002113	82.17	gold quality
blood	UBERON:0000178	80.33	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	80.26	gold quality
liver	UBERON:0002107	79.89	gold quality
adult mammalian kidney	UBERON:0000082	79.29	gold quality
monocyte	CL:0000576	78.53	gold quality
stomach	UBERON:0000945	78.47	gold quality
muscle of leg	UBERON:0001383	77.97	gold quality
vermiform appendix	UBERON:0001154	77.49	gold quality
endometrium	UBERON:0001295	76.90	gold quality
placenta	UBERON:0001987	74.68	gold quality
gastrocnemius	UBERON:0001388	74.05	gold quality
heart	UBERON:0000948	73.11	gold quality
islet of Langerhans	UBERON:0000006	72.54	gold quality
Brodmann (1909) area 9	UBERON:0013540	72.36	gold quality
adrenal gland	UBERON:0002369	71.60	gold quality
body of pancreas	UBERON:0001150	71.47	gold quality
substantia nigra	UBERON:0002038	71.16	gold quality
right atrium auricular region	UBERON:0006631	71.13	gold quality
tibial artery	UBERON:0007610	69.99	gold quality
right lobe of liver	UBERON:0001114	69.94	gold quality
popliteal artery	UBERON:0002250	69.91	gold quality
heart left ventricle	UBERON:0002084	69.69	gold quality
left adrenal gland cortex	UBERON:0035825	69.65	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.98

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 8)

• we show that GAPDH and beta-actin are direct targets of miR-644a. (PMID:23091630)
• Downregulation of miR-644a plays an important role in promoting both aggressiveness and stem-like traits of ESCC cells, suggesting that miR-644a may be useful as a novel prognostic biomarker or therapeutic target for the disease (PMID:27407092)
• miR-644a/CTBP1/p53 have roles in suppressing breast cancer drug resistance by inhibiting cell survival and epithelial-mesenchymal transition (PMID:27409664)
• through targeting CtBP1-mediated suppression of the Epithelial-mesenchymal transition process, miR-644a might suppress the tumor metastasis of gastric cancer cells (PMID:27983935)
• data revealed that NF-kappaB may affect the transcript of MEG3. MEG3 overexpression inhibited the proliferation of HCC cells, at least in part by affecting miR-664mediated regulation of ADH4. Together, these results suggest that MEG3 is a suppressor of tumor which acts in part through “sponging” miR-664. (PMID:28374914)
• miR-644a promotes apoptosis in HCC cells by inhibiting HSF1 (PMID:29898735)
• Low miR644a expression is associated with prostate cancer. (PMID:30808676)
• Short-term ambient particulate air pollution exposure, microRNAs, blood pressure and lung function. (PMID:34673158)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.