MIR645

Summary

MIR645 (microRNA 645, HGNC:32901) is a microRNA gene on chromosome 20q13.13.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693230 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32901
Approved symbol	MIR645
Name	microRNA 645
Location	20q13.13
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-645
Ensembl gene	ENSG00000208018
Ensembl biotype	miRNA
Entrez	693230
RNAcentral	URS000075AEA1 — miRNA, 94 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385283

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385283 — 1 exons

Exon	Start	End
ENSE00001500289	50585786	50585879

Expression profiles

Bgee: expression breadth ubiquitous, 109 present calls, max score 88.27.

Top tissues by expression

109 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	88.27	gold quality
calcaneal tendon	UBERON:0003701	86.91	gold quality
bone marrow	UBERON:0002371	84.49	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	80.10	gold quality
blood	UBERON:0000178	79.29	gold quality
duodenum	UBERON:0002114	79.25	gold quality
adult mammalian kidney	UBERON:0000082	78.90	gold quality
vermiform appendix	UBERON:0001154	78.53	gold quality
monocyte	CL:0000576	78.22	gold quality
kidney	UBERON:0002113	77.98	gold quality
adrenal tissue	UBERON:0018303	77.86	gold quality
muscle of leg	UBERON:0001383	77.69	gold quality
left uterine tube	UBERON:0001303	77.62	gold quality
corpus callosum	UBERON:0002336	77.31	gold quality
granulocyte	CL:0000094	76.81	gold quality
gastrocnemius	UBERON:0001388	76.59	gold quality
liver	UBERON:0002107	75.47	gold quality
ectocervix	UBERON:0012249	75.34	gold quality
endocervix	UBERON:0000458	75.02	gold quality
heart left ventricle	UBERON:0002084	75.00	gold quality
heart	UBERON:0000948	74.34	gold quality
right adrenal gland	UBERON:0001233	74.32	gold quality
stomach	UBERON:0000945	74.29	gold quality
adrenal gland	UBERON:0002369	74.21	gold quality
fundus of stomach	UBERON:0001160	74.07	gold quality
left adrenal gland	UBERON:0001234	73.72	gold quality
omental fat pad	UBERON:0010414	73.63	gold quality
islet of Langerhans	UBERON:0000006	73.33	gold quality
left adrenal gland cortex	UBERON:0035825	73.30	gold quality
right adrenal gland cortex	UBERON:0035827	73.27	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.29

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 8)

• Data suggests that miR-645 functions as an oncogene in human adenocarcinoma of gastric esophageal junction by, at least partially through,targeting IFIT2. (PMID:25174799)
• LINC00161 is an essential regulator in cisplatin-induced apoptosis, and the LINC00161-miR-645-IFIT2 signalling axis plays an important role in reducing osteosarcoma chemoresistance. (PMID:27609068)
• Downregulation of microRNA-645 suppresses breast cancer cell metastasis via targeting DCDC2 (PMID:29028086)
• Downregulated miR-645 had tumor-suppressive effect on RCCC metastasis and proliferation via targeting glycerol kinase 5. (PMID:29131260)
• miR-645 was up-regulated in osteosarcoma tissues and could promote osteosarcoma cell migration through directly inhibiting the tumor suppressor NME2 (PMID:29956840)
• MicroRNA-645 represses hepatocellular carcinoma progression by inhibiting SOX30-mediated p53 transcriptional activation (PMID:30312695)
• MiR-645 regulates the proliferation and apoptosis of diffuse large B-cell lymphoma by targeting DACH1. (PMID:32529465)
• MiR-645 promotes proliferation and migration of non-small cell lung cancer cells by targeting TP53I11. (PMID:32572880)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.