MIR646

Summary

MIR646 (microRNA 646, HGNC:32902) is a microRNA gene on chromosome 20q13.33.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693231 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32902
Approved symbol	MIR646
Name	microRNA 646
Location	20q13.33
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-646
Ensembl gene	ENSG00000207802
Ensembl biotype	miRNA
Entrez	693231
RNAcentral	URS000075CDB8 — miRNA, 94 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385067

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385067 — 1 exons

Exon	Start	End
ENSE00001500073	60308474	60308567

Expression profiles

Bgee: expression breadth broad, 87 present calls, max score 86.35.

Top tissues by expression

87 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adult mammalian kidney	UBERON:0000082	86.35	gold quality
adrenal tissue	UBERON:0018303	80.02	gold quality
blood	UBERON:0000178	79.64	gold quality
monocyte	CL:0000576	77.06	gold quality
bone marrow	UBERON:0002371	76.15	gold quality
placenta	UBERON:0001987	74.68	gold quality
kidney	UBERON:0002113	74.56	gold quality
gastrocnemius	UBERON:0001388	73.70	gold quality
right atrium auricular region	UBERON:0006631	73.20	gold quality
corpus callosum	UBERON:0002336	72.86	gold quality
endometrium	UBERON:0001295	72.47	gold quality
body of pancreas	UBERON:0001150	72.36	gold quality
prefrontal cortex	UBERON:0000451	71.55	gold quality
heart	UBERON:0000948	71.35	gold quality
heart left ventricle	UBERON:0002084	70.62	gold quality
muscle layer of sigmoid colon	UBERON:0035805	70.43	gold quality
substantia nigra	UBERON:0002038	70.26	gold quality
body of uterus	UBERON:0009853	69.68	gold quality
myometrium	UBERON:0001296	69.58	gold quality
adrenal gland	UBERON:0002369	69.35	gold quality
gall bladder	UBERON:0002110	69.23	gold quality
ascending aorta	UBERON:0001496	69.05	gold quality
thoracic aorta	UBERON:0001515	69.01	gold quality
stomach	UBERON:0000945	68.99	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.57	gold quality
colon	UBERON:0001155	68.55	gold quality
right adrenal gland	UBERON:0001233	68.50	gold quality
right adrenal gland cortex	UBERON:0035827	68.40	gold quality
left coronary artery	UBERON:0001626	68.38	gold quality
liver	UBERON:0002107	68.34	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.21

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 21)

• miR-646 SNP rs6513497 may contribute to the susceptibility of HCC. (PMID:25177719)
• miR-646 is a key negative regulator of EGFR pathway in lung cancer. (PMID:27462913)
• MiR-646 expression was downregulated in gastric cancer tissues compared with adjacent normal tissues. Low miR-646 expression is associated with malignant progression. miR-646 inhibited gastric cancer cell proliferation and the epithelial-mesenchymal transition progression in gastric cancer cells by targeting FOXK1. (PMID:28632723)
• Dysregulated miR-646 and MIIP expression was correlated with advanced tumor stage, lymphatic invasion, metastasis and shorter overall survival in Pancreatic cancer patients. (PMID:29343850)
• HOTAIR could regulate NPM1 by interacting with miR-646, thereby governing the viability, migration, and invasion of endometrial cancer cells. (PMID:29466670)
• Androgen receptor reverses the oncometabolite R-2-hydroxyglutarate-induced prostate cancer cell invasion via suppressing the circRNA-51217/miRNA-646/TGFbeta1/p-Smad2/3 signaling. (PMID:31846689)
• circRNA circ-CCND1 promotes the proliferation of laryngeal squamous cell carcinoma through elevating CCND1 expression via interacting with HuR and miR-646. (PMID:31951319)
• Long Noncoding MT1JP Enhanced the Inhibitory Effects of miR-646 on FGF2 in Osteosarcoma. (PMID:32196384)
• miR-646 acted as a target of hsa_circ_0041795 and VEGFC was a direct target of miR-646. (PMID:32259632)
• Circular RNA has_circ_0000527 participates in proliferation, invasion and migration of retinoblastoma cells via miR-646/BCL-2 axis. (PMID:32266733)
• MiR-646 suppresses proliferation and metastasis of non-small cell lung cancer by repressing FGF2 and CCND2. (PMID:32347652)
• CircRNA WHSC1 targets the miR-646/NPM1 pathway to promote the development of endometrial cancer. (PMID:32378344)
• MiR-646 prevents proliferation and progression of human breast cancer cell lines by suppressing HDAC2 expression. (PMID:32777446)
• MiR-646 regulates proliferation and migration of laryngeal carcinoma through the PI3K/AKT pathway via targeting GPX1. (PMID:33150676)
• Oxidative Stress-Induced circHBEGF Promotes Extracellular Matrix Production via Regulating miR-646/EGFR in Human Trabecular Meshwork Cells. (PMID:33335643)
• hsa_circ_0001610 knockdown modulates miR-646-STAT3 axis to suppress endometrial carcinoma progression. (PMID:33822442)
• Circ_0001955 Acts as a miR-646 Sponge to Promote the Proliferation, Metastasis and Angiogenesis of Hepatocellular Carcinoma. (PMID:34021822)
• Circ_0016760 accelerates non-small-cell lung cancer progression through miR-646/AKT3 signaling in vivo and in vitro. (PMID:34658165)
• Circ-PKD2 promotes Atg13-mediated autophagy by inhibiting miR-646 to increase the sensitivity of cisplatin in oral squamous cell carcinomas. (PMID:35220397)
• Down-Regulation of circCOL1A2 Suppresses the Dysfunction of Diabetes-Related Retinal Microvascular Endothelial Cells via miR-646/FGF7 Axis. (PMID:35924466)
• MicroRNA-646 inhibits the proliferation of ovarian granulosa cells via insulin-like growth factor 1 (IGF-1) in polycystic ovarian syndrome (PCOS). (PMID:37155307)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.