MIR646HG

Summary

MIR646HG (MIR646 host gene, HGNC:27659) is a long non-coding RNA gene on chromosome 20q13.33.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27659
Approved symbol	MIR646HG
Name	MIR646 host gene
Location	20q13.33
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000228340
Ensembl biotype	lncRNA
Entrez	284757
RNAcentral	URS000038B483 — lncRNA, 2043 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 161 — 161 lncRNA

ENST00000421257, ENST00000426753, ENST00000427691, ENST00000427820, ENST00000428772, ENST00000431181, ENST00000432910, ENST00000437035, ENST00000439507, ENST00000457508, ENST00000458422, ENST00000625080, ENST00000647608, ENST00000652813, ENST00000653415, ENST00000653451, ENST00000653739, ENST00000653814, ENST00000654038, ENST00000654258, ENST00000654306, ENST00000654397, ENST00000654422, ENST00000654943, ENST00000654960, ENST00000655034, ENST00000655544, ENST00000655737, ENST00000655816, ENST00000656236, ENST00000656658, ENST00000657038, ENST00000657541, ENST00000657582, ENST00000657952, ENST00000658147, ENST00000658620, ENST00000659494, ENST00000659500, ENST00000659856, ENST00000659996, ENST00000660044, ENST00000660093, ENST00000660397, ENST00000660831, ENST00000660970, ENST00000661019, ENST00000661179, ENST00000661569, ENST00000662456, ENST00000662790, ENST00000662972, ENST00000663065, ENST00000663127, ENST00000663582, ENST00000663620, ENST00000664016, ENST00000664147, ENST00000664219, ENST00000664304, ENST00000664403, ENST00000664414, ENST00000665017, ENST00000665114, ENST00000665518, ENST00000666811, ENST00000667249, ENST00000667581, ENST00000667664, ENST00000668055, ENST00000668275, ENST00000668954, ENST00000671305, ENST00000671388, ENST00000685502, ENST00000686863, ENST00000687520, ENST00000690445, ENST00000691246, ENST00000692368, ENST00000701068, ENST00000701578, ENST00000715828, ENST00000745816, ENST00000810784, ENST00000816685, ENST00000816686, ENST00000816687, ENST00000839597, ENST00000839598, ENST00000839599, ENST00000839600, ENST00000839601, ENST00000839602, ENST00000839603, ENST00000839604, ENST00000839605, ENST00000839606, ENST00000839607, ENST00000839608, ENST00000839609, ENST00000839610, ENST00000839611, ENST00000839612, ENST00000839613, ENST00000839614, ENST00000839615, ENST00000839616, ENST00000839617, ENST00000839618, ENST00000839619, ENST00000839620, ENST00000839621, ENST00000839622, ENST00000839623, ENST00000839624, ENST00000839625, ENST00000839626, ENST00000839627, ENST00000839628, ENST00000839629, ENST00000839630, ENST00000839631, ENST00000839632, ENST00000839633, ENST00000839634, ENST00000839635, ENST00000839636, ENST00000839637, ENST00000839638, ENST00000839639, ENST00000839640, ENST00000839641, ENST00000839642, ENST00000839643, ENST00000839644, ENST00000839645, ENST00000839646, ENST00000839647, ENST00000839648, ENST00000839649, ENST00000839650, ENST00000839651, ENST00000839652, ENST00000839653, ENST00000839654, ENST00000839655, ENST00000839656, ENST00000839657, ENST00000839658, ENST00000839659, ENST00000839660, ENST00000839661, ENST00000839662, ENST00000839663, ENST00000839664, ENST00000839665, ENST00000839666, ENST00000839667, ENST00000839668, ENST00000839669

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000421257 — 3 exons

Exon	Start	End
ENSE00001630611	60180879	60180913
ENSE00001677187	60330873	60331584
ENSE00001775820	60313310	60313387

Expression profiles

Bgee: expression breadth ubiquitous, 183 present calls, max score 91.04.

FANTOM5 (CAGE): breadth broad, TPM avg 1.5550 / max 126.7675, expressed in 332 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
185657	1.5550	332
185665	0.8277	364
185680	0.3051	148
185664	0.2601	138

Top tissues by expression

243 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	91.04	gold quality
thymus	UBERON:0002370	89.87	gold quality
sperm	CL:0000019	89.50	gold quality
bone marrow cell	CL:0002092	86.65	gold quality
left testis	UBERON:0004533	85.09	gold quality
right testis	UBERON:0004534	84.74	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.92	gold quality
sural nerve	UBERON:0015488	83.58	gold quality
testis	UBERON:0000473	83.23	gold quality
granulocyte	CL:0000094	82.13	gold quality
blood	UBERON:0000178	81.88	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.66	gold quality
trabecular bone tissue	UBERON:0002483	81.41	gold quality
leukocyte	CL:0000738	78.61	gold quality
monocyte	CL:0000576	78.60	gold quality
apex of heart	UBERON:0002098	77.91	gold quality
bone marrow	UBERON:0002371	77.71	gold quality
tibial nerve	UBERON:0001323	76.93	gold quality
oocyte	CL:0000023	74.76	gold quality
gastrocnemius	UBERON:0001388	73.93	gold quality
right uterine tube	UBERON:0001302	73.35	gold quality
colonic epithelium	UBERON:0000397	73.11	gold quality
muscle of leg	UBERON:0001383	73.04	gold quality
adenohypophysis	UBERON:0002196	72.73	gold quality
secondary oocyte	CL:0000655	72.56	gold quality
heart left ventricle	UBERON:0002084	72.43	gold quality
pituitary gland	UBERON:0000007	72.26	gold quality
cardiac ventricle	UBERON:0002082	72.22	gold quality
right lung	UBERON:0002167	72.18	gold quality
endocervix	UBERON:0000458	71.85	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.53

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• MiR-646 regulates proliferation and migration of laryngeal carcinoma through the PI3K/AKT pathway via targeting GPX1. (PMID:33150676)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.