MIR647

Summary

MIR647 (microRNA 647, HGNC:32903) is a microRNA gene on chromosome 20q13.33.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693232 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32903
Approved symbol	MIR647
Name	microRNA 647
Location	20q13.33
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-647
Ensembl gene	ENSG00000207554
Ensembl biotype	miRNA
Entrez	693232
RNAcentral	URS000075B0C4 — miRNA, 96 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384823

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384823 — 1 exons

Exon	Start	End
ENSE00001499830	63942631	63942726

Expression profiles

Bgee: expression breadth ubiquitous, 117 present calls, max score 98.99.

Top tissues by expression

117 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right uterine tube	UBERON:0001302	98.99	gold quality
right hemisphere of cerebellum	UBERON:0014890	98.83	gold quality
left ovary	UBERON:0002119	98.74	gold quality
right ovary	UBERON:0002118	98.67	gold quality
metanephros cortex	UBERON:0010533	98.61	gold quality
cerebellar hemisphere	UBERON:0002245	98.27	gold quality
body of uterus	UBERON:0009853	98.17	gold quality
endocervix	UBERON:0000458	98.08	gold quality
small intestine Peyer’s patch	UBERON:0003454	98.05	gold quality
ovary	UBERON:0000992	98.02	gold quality
ectocervix	UBERON:0012249	97.96	gold quality
fundus of stomach	UBERON:0001160	97.94	gold quality
vagina	UBERON:0000996	97.92	gold quality
transverse colon	UBERON:0001157	97.84	gold quality
tibial nerve	UBERON:0001323	97.75	gold quality
small intestine	UBERON:0002108	97.72	gold quality
left lobe of thyroid gland	UBERON:0001120	97.70	gold quality
right lobe of thyroid gland	UBERON:0001119	97.68	gold quality
body of pancreas	UBERON:0001150	97.68	gold quality
left uterine tube	UBERON:0001303	97.64	gold quality
lower esophagus mucosa	UBERON:0035834	97.64	gold quality
minor salivary gland	UBERON:0001830	97.59	gold quality
right lung	UBERON:0002167	97.48	gold quality
muscle layer of sigmoid colon	UBERON:0035805	97.33	gold quality
saliva-secreting gland	UBERON:0001044	97.30	gold quality
body of stomach	UBERON:0001161	97.25	gold quality
lower esophagus	UBERON:0013473	97.16	gold quality
lower esophagus muscularis layer	UBERON:0035833	97.16	gold quality
thyroid gland	UBERON:0002046	97.14	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	97.11	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.76

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 13)

• Low miR-647 expression is associated with gastric cancer. (PMID:28098914)
• miR-647 functions as a tumor metastasis suppressor in gastric cancer by targeting SRF/MYH9 axis. (PMID:28900514)
• miR-647 and miR-1914 promote the proliferation and migration equivalently by downregulating NFIX in CRC cells in vitro. (PMID:28990086)
• The expression levels of miR647 were downregulated in gastric cancer (GC) tissues from patients with metastasis and in the vincristineresistant SGC7901 (SGC7901/VCR) GC cell line. miR-647 modulates drug resistance by reducing the expression levels of ANK2, FAK, MMP2, MMP12, CD44 and SNAIL2. (PMID:29328428)
• miR647 functions as a tumor promoter in Gastric Cancer by repressing TP73. (PMID:30106095)
• MiR-647 promotes proliferation and migration of ox-LDL-treated vascular smooth muscle cells through regulating PTEN/PI3K/AKT pathway. (PMID:31486513)
• the present results indicated that circFAM53B could be a competing endogenous RNA (ceRNA) to competitively sponge miR646 and miR647 to upregulate VAMP2 and MDM2 expression at the posttranscriptional level, thus mediating the cellular behaviors of Ovarian cancer cells (PMID:31638250)
• Long noncoding RNA PROX1-AS1 promotes tumor progression and aggressiveness by sponging miR-647 in gastric cancer. (PMID:31726808)
• MiR-647 promotes cisplatin-induced cell apoptosis via downregulating IGF2 in non-small cell lung cancer. (PMID:31726809)
• miR-647 inhibits glioma cell proliferation, colony formation and invasion by regulating HOXA9. (PMID:31881106)
• Deregulation of circ_003912 contributes to pathogenesis of erosive oral lichen planus by via sponging microRNA-123, -647 and -31 and upregulating FOXP3. (PMID:34670484)
• EIF4A3-induced circZFAND6 promotes breast cancer proliferation and metastasis through the miR-647/FASN axis. (PMID:37127184)
• m6A-modified circNFIX promotes ovarian cancer progression and immune escape via activating IL-6R/JAK1/STAT3 signaling by sponging miR-647. (PMID:37713785)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.