MIR648

Summary

MIR648 (microRNA 648, HGNC:32904) is a microRNA gene on chromosome 22q11.21.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693233 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32904
Approved symbol	MIR648
Name	microRNA 648
Location	22q11.21
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-648
Ensembl gene	ENSG00000207780
Ensembl biotype	miRNA
OMIM	616205
Entrez	693233
RNAcentral	URS000063524F — miRNA, 94 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385046

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385046 — 1 exons

Exon	Start	End
ENSE00001500053	17980868	17980961

Expression profiles

Bgee: expression breadth broad, 77 present calls, max score 92.59.

Top tissues by expression

77 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
corpus callosum	UBERON:0002336	92.59	gold quality
sural nerve	UBERON:0015488	89.31	gold quality
adrenal tissue	UBERON:0018303	85.60	gold quality
adult mammalian kidney	UBERON:0000082	82.11	gold quality
prefrontal cortex	UBERON:0000451	80.32	gold quality
blood	UBERON:0000178	79.84	gold quality
bone marrow	UBERON:0002371	77.84	gold quality
monocyte	CL:0000576	77.11	gold quality
muscle of leg	UBERON:0001383	75.50	gold quality
calcaneal tendon	UBERON:0003701	74.43	gold quality
gastrocnemius	UBERON:0001388	73.41	gold quality
stomach	UBERON:0000945	71.83	gold quality
heart	UBERON:0000948	71.35	gold quality
nucleus accumbens	UBERON:0001882	70.55	gold quality
heart left ventricle	UBERON:0002084	70.25	gold quality
body of pancreas	UBERON:0001150	70.22	gold quality
liver	UBERON:0002107	69.98	gold quality
right adrenal gland	UBERON:0001233	69.96	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	69.68	gold quality
tibial artery	UBERON:0007610	69.54	gold quality
right lobe of liver	UBERON:0001114	69.29	gold quality
colon	UBERON:0001155	68.59	gold quality
intestine	UBERON:0000160	68.12	gold quality
frontal cortex	UBERON:0001870	67.76	gold quality
endometrium	UBERON:0001295	67.52	gold quality
thoracic aorta	UBERON:0001515	67.27	gold quality
left adrenal gland	UBERON:0001234	67.20	gold quality
hypothalamus	UBERON:0001898	67.18	gold quality
muscle layer of sigmoid colon	UBERON:0035805	67.16	gold quality
body of stomach	UBERON:0001161	67.07	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.86

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• studies provide a novel link wherein PlGF-mediated downregulation of PAX5 attenuates miR-648 expression leading to increased ET-1 levels (PMID:25403488)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.