MIR649

Summary

MIR649 (microRNA 649, HGNC:32905) is a microRNA gene on chromosome 22q11.21.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693234 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32905
Approved symbol	MIR649
Name	microRNA 649
Location	22q11.21
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-649
Ensembl gene	ENSG00000207575
Ensembl biotype	miRNA
Entrez	693234
RNAcentral	URS00006DE1AC — miRNA, 97 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384843

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384843 — 1 exons

Exon	Start	End
ENSE00001499850	21034176	21034272

Expression profiles

Bgee: expression breadth broad, 51 present calls, max score 88.97.

Top tissues by expression

51 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	88.97	gold quality
muscle of leg	UBERON:0001383	76.98	gold quality
gastrocnemius	UBERON:0001388	76.82	gold quality
blood	UBERON:0000178	75.90	gold quality
body of stomach	UBERON:0001161	74.01	gold quality
placenta	UBERON:0001987	72.74	gold quality
right atrium auricular region	UBERON:0006631	71.97	gold quality
islet of Langerhans	UBERON:0000006	71.86	gold quality
substantia nigra	UBERON:0002038	71.72	gold quality
muscle layer of sigmoid colon	UBERON:0035805	71.00	gold quality
heart left ventricle	UBERON:0002084	70.02	gold quality
ovary	UBERON:0000992	69.19	gold quality
colon	UBERON:0001155	68.53	gold quality
body of uterus	UBERON:0009853	68.48	gold quality
transverse colon	UBERON:0001157	67.99	gold quality
omental fat pad	UBERON:0010414	67.92	gold quality
left ovary	UBERON:0002119	67.18	gold quality
vagina	UBERON:0000996	67.06	gold quality
esophagus mucosa	UBERON:0002469	66.97	gold quality
right adrenal gland	UBERON:0001233	66.86	gold quality
left adrenal gland	UBERON:0001234	66.84	gold quality
amygdala	UBERON:0001876	66.68	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.55	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.39	gold quality
tibial nerve	UBERON:0001323	65.71	gold quality
Ammon’s horn	UBERON:0001954	65.67	gold quality
right adrenal gland cortex	UBERON:0035827	65.42	gold quality
nucleus accumbens	UBERON:0001882	65.05	gold quality
ascending aorta	UBERON:0001496	64.39	gold quality
cerebellar hemisphere	UBERON:0002245	63.71	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.65

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Taken together, this present study indicates that miR-649 promotes herpes simplex virus type 1 replication through regulation of the MALT1-mediated antiviral signaling pathway and suggests a promising target for antiviral therapies. (PMID:27813118)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.