MIR6499

Summary

MIR6499 (microRNA 6499, HGNC:49962) is a microRNA gene on chromosome 5q33.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465246 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49962
Approved symbol	MIR6499
Name	microRNA 6499
Location	5q33.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6499
Ensembl gene	ENSG00000276622
Ensembl biotype	miRNA
Entrez	102465246
RNAcentral	URS000075E8F9 — ncRNA, 62 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000621322

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000621322 — 1 exons

Exon	Start	End
ENSE00003731567	151522087	151522148

Expression profiles

Bgee: expression breadth broad, 55 present calls, max score 86.91.

Top tissues by expression

55 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right hemisphere of cerebellum	UBERON:0014890	86.91	gold quality
cerebellar hemisphere	UBERON:0002245	84.26	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.10	gold quality
left ovary	UBERON:0002119	80.82	gold quality
myometrium	UBERON:0001296	79.35	gold quality
calcaneal tendon	UBERON:0003701	78.19	gold quality
blood	UBERON:0000178	77.81	gold quality
Brodmann (1909) area 9	UBERON:0013540	76.12	gold quality
gastrocnemius	UBERON:0001388	75.44	gold quality
skin of abdomen	UBERON:0001416	75.30	gold quality
ectocervix	UBERON:0012249	75.30	gold quality
lower esophagus muscularis layer	UBERON:0035833	74.82	gold quality
liver	UBERON:0002107	74.28	gold quality
stomach	UBERON:0000945	74.09	gold quality
zone of skin	UBERON:0000014	73.84	gold quality
lung	UBERON:0002048	73.45	gold quality
vagina	UBERON:0000996	73.04	gold quality
skin of leg	UBERON:0001511	72.72	gold quality
right frontal lobe	UBERON:0002810	72.44	gold quality
esophagus	UBERON:0001043	72.22	gold quality
body of pancreas	UBERON:0001150	72.20	gold quality
esophagus mucosa	UBERON:0002469	72.17	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	71.06	gold quality
tibial artery	UBERON:0007610	70.75	gold quality
putamen	UBERON:0001874	69.95	gold quality
urinary bladder	UBERON:0001255	69.30	gold quality
subcutaneous adipose tissue	UBERON:0002190	69.01	gold quality
minor salivary gland	UBERON:0001830	68.93	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.44	gold quality
left adrenal gland cortex	UBERON:0035825	67.74	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.34

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.