MIR6500

Summary

MIR6500 (microRNA 6500, HGNC:49935) is a microRNA gene on chromosome 1p32.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466656 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49935
Approved symbol	MIR6500
Name	microRNA 6500
Location	1p32.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6500
Ensembl gene	ENSG00000275816
Ensembl biotype	miRNA
Entrez	102466656
RNAcentral	URS000075C9B9 — ncRNA, 86 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000622700

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000622700 — 1 exons

Exon	Start	End
ENSE00003750196	51060018	51060103

Expression profiles

Bgee: expression breadth broad, 83 present calls, max score 98.49.

Top tissues by expression

83 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	98.49	gold quality
bone marrow	UBERON:0002371	85.83	gold quality
kidney	UBERON:0002113	83.26	gold quality
adrenal tissue	UBERON:0018303	82.47	gold quality
adult mammalian kidney	UBERON:0000082	78.45	gold quality
monocyte	CL:0000576	77.17	gold quality
blood	UBERON:0000178	76.24	gold quality
gastrocnemius	UBERON:0001388	74.17	gold quality
calcaneal tendon	UBERON:0003701	73.82	gold quality
islet of Langerhans	UBERON:0000006	73.75	gold quality
liver	UBERON:0002107	73.00	gold quality
body of pancreas	UBERON:0001150	71.48	gold quality
heart	UBERON:0000948	71.29	gold quality
heart left ventricle	UBERON:0002084	70.39	gold quality
putamen	UBERON:0001874	69.82	gold quality
stomach	UBERON:0000945	69.78	gold quality
endometrium	UBERON:0001295	69.37	gold quality
endocervix	UBERON:0000458	68.95	gold quality
granulocyte	CL:0000094	68.53	gold quality
left coronary artery	UBERON:0001626	68.47	gold quality
ectocervix	UBERON:0012249	68.11	gold quality
right atrium auricular region	UBERON:0006631	68.01	gold quality
right coronary artery	UBERON:0001625	67.82	gold quality
thoracic aorta	UBERON:0001515	67.33	gold quality
hypothalamus	UBERON:0001898	67.13	gold quality
tibial artery	UBERON:0007610	67.04	gold quality
Ammon’s horn	UBERON:0001954	66.99	gold quality
popliteal artery	UBERON:0002250	66.99	gold quality
intestine	UBERON:0000160	66.98	gold quality
ascending aorta	UBERON:0001496	66.98	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.10

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Data indicate that three genes, KIF14, NCAPG and CENPE that were upregulated in Pediatric high-grade gliomas (pHGGs) and were direct miR-137 or miR-6500-3p targets. (PMID:26933822)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.