MIR6503

Summary

MIR6503 (microRNA 6503, HGNC:49968) is a microRNA gene on chromosome 11q12.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465250 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49968
Approved symbol	MIR6503
Name	microRNA 6503
Location	11q12.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6503
Ensembl gene	ENSG00000275344
Ensembl biotype	miRNA
Entrez	102465250
RNAcentral	URS000075B4DB — ncRNA, 86 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000622884

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000622884 — 1 exons

Exon	Start	End
ENSE00003713477	60209071	60209156

Expression profiles

Bgee: expression breadth broad, 96 present calls, max score 84.74.

Top tissues by expression

96 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	84.74	gold quality
right coronary artery	UBERON:0001625	83.08	gold quality
vermiform appendix	UBERON:0001154	81.20	gold quality
granulocyte	CL:0000094	80.58	gold quality
bone marrow	UBERON:0002371	80.10	gold quality
right adrenal gland cortex	UBERON:0035827	78.70	gold quality
calcaneal tendon	UBERON:0003701	78.66	gold quality
right adrenal gland	UBERON:0001233	76.60	gold quality
mucosa of stomach	UBERON:0001199	76.57	gold quality
blood	UBERON:0000178	76.52	gold quality
placenta	UBERON:0001987	76.43	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	76.41	gold quality
liver	UBERON:0002107	76.34	gold quality
adrenal gland	UBERON:0002369	76.03	gold quality
subcutaneous adipose tissue	UBERON:0002190	75.92	gold quality
lower esophagus muscularis layer	UBERON:0035833	75.90	gold quality
lower esophagus	UBERON:0013473	75.83	gold quality
spleen	UBERON:0002106	75.79	gold quality
small intestine	UBERON:0002108	75.74	gold quality
left adrenal gland	UBERON:0001234	75.70	gold quality
adrenal tissue	UBERON:0018303	75.68	gold quality
small intestine Peyer’s patch	UBERON:0003454	75.60	gold quality
adipose tissue	UBERON:0001013	75.15	gold quality
muscle of leg	UBERON:0001383	74.99	gold quality
intestine	UBERON:0000160	74.52	gold quality
body of stomach	UBERON:0001161	74.51	gold quality
stomach	UBERON:0000945	74.24	gold quality
colon	UBERON:0001155	74.06	gold quality
omental fat pad	UBERON:0010414	74.06	gold quality
gastrocnemius	UBERON:0001388	74.03	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.15

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.