MIR6504

Summary

MIR6504 (microRNA 6504, HGNC:49976) is a microRNA gene on chromosome 16q23.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465251 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49976
Approved symbol	MIR6504
Name	microRNA 6504
Location	16q23.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6504
Ensembl gene	ENSG00000275109
Ensembl biotype	miRNA
Entrez	102465251
RNAcentral	URS000075C26E — ncRNA, 61 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000613520

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000613520 — 1 exons

Exon	Start	End
ENSE00003730445	81611348	81611408

Expression profiles

Bgee: expression breadth broad, 54 present calls, max score 79.66.

Top tissues by expression

54 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	79.66	gold quality
heart	UBERON:0000948	73.82	gold quality
islet of Langerhans	UBERON:0000006	73.67	gold quality
gastrocnemius	UBERON:0001388	73.65	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	72.96	gold quality
stomach	UBERON:0000945	72.83	gold quality
monocyte	CL:0000576	72.70	gold quality
kidney	UBERON:0002113	72.32	gold quality
smooth muscle tissue	UBERON:0001135	71.74	gold quality
liver	UBERON:0002107	71.30	gold quality
adult mammalian kidney	UBERON:0000082	71.00	gold quality
body of stomach	UBERON:0001161	70.73	gold quality
heart left ventricle	UBERON:0002084	69.48	gold quality
intestine	UBERON:0000160	69.41	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	69.40	gold quality
Brodmann (1909) area 9	UBERON:0013540	68.30	gold quality
colon	UBERON:0001155	68.23	gold quality
lung	UBERON:0002048	67.89	gold quality
omental fat pad	UBERON:0010414	67.63	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.89	gold quality
esophagus mucosa	UBERON:0002469	66.63	gold quality
transverse colon	UBERON:0001157	66.29	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.95	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.84	gold quality
myometrium	UBERON:0001296	65.75	gold quality
thoracic mammary gland	UBERON:0005200	65.66	gold quality
ascending aorta	UBERON:0001496	65.64	gold quality
anterior cingulate cortex	UBERON:0009835	65.64	gold quality
skin of abdomen	UBERON:0001416	65.16	gold quality
vagina	UBERON:0000996	65.15	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.28

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.