MIR6505

Summary

MIR6505 (microRNA 6505, HGNC:50104) is a microRNA gene on chromosome 12q13.11.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466657 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50104
Approved symbol	MIR6505
Name	microRNA 6505
Location	12q13.11
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6505
Ensembl gene	ENSG00000275770
Ensembl biotype	miRNA
Entrez	102466657
RNAcentral	URS000075D860 — miRNA, 71 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000617206

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000617206 — 1 exons

Exon	Start	End
ENSE00003723686	48132797	48132867

Expression profiles

Bgee: expression breadth broad, 98 present calls, max score 89.16.

Top tissues by expression

98 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	89.16	gold quality
adrenal tissue	UBERON:0018303	85.29	gold quality
vermiform appendix	UBERON:0001154	84.61	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.29	gold quality
monocyte	CL:0000576	79.38	gold quality
muscle of leg	UBERON:0001383	78.78	gold quality
tonsil	UBERON:0002372	77.57	gold quality
prefrontal cortex	UBERON:0000451	77.50	gold quality
calcaneal tendon	UBERON:0003701	76.72	gold quality
gastrocnemius	UBERON:0001388	76.36	gold quality
endometrium	UBERON:0001295	76.24	gold quality
right hemisphere of cerebellum	UBERON:0014890	76.20	gold quality
cerebellar hemisphere	UBERON:0002245	75.65	gold quality
apex of heart	UBERON:0002098	75.47	gold quality
left adrenal gland cortex	UBERON:0035825	75.38	gold quality
placenta	UBERON:0001987	75.11	gold quality
heart left ventricle	UBERON:0002084	75.00	gold quality
heart	UBERON:0000948	74.80	gold quality
adrenal gland	UBERON:0002369	74.77	gold quality
descending thoracic aorta	UBERON:0002345	74.68	gold quality
blood	UBERON:0000178	74.23	gold quality
left adrenal gland	UBERON:0001234	74.12	gold quality
kidney	UBERON:0002113	74.03	gold quality
right atrium auricular region	UBERON:0006631	73.80	gold quality
lymph node	UBERON:0000029	73.78	gold quality
right adrenal gland	UBERON:0001233	72.51	gold quality
adult mammalian kidney	UBERON:0000082	72.24	gold quality
right lobe of liver	UBERON:0001114	72.11	gold quality
metanephros cortex	UBERON:0010533	71.69	gold quality
right adrenal gland cortex	UBERON:0035827	71.10	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.18

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.