MIR6506

Summary

MIR6506 (microRNA 6506, HGNC:50158) is a microRNA gene on chromosome 16p13.11.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465252 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50158
Approved symbol	MIR6506
Name	microRNA 6506
Location	16p13.11
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6506
Ensembl gene	ENSG00000284184
Ensembl biotype	miRNA
Entrez	102465252
RNAcentral	URS000075B6F9 — ncRNA, 66 nt, 14 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000614811

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000614811 — 1 exons

Exon	Start	End
ENSE00003725527	15611030	15611095

Expression profiles

Bgee: expression breadth tissue_specific, 6 present calls, max score 85.88.

Top tissues by expression

6 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
heart left ventricle	UBERON:0002084	85.88	gold quality
skeletal muscle tissue	UBERON:0001134	85.39	gold quality
muscle of leg	UBERON:0001383	83.69	gold quality
tibial artery	UBERON:0007610	64.14	gold quality
blood	UBERON:0000178	58.10	gold quality
right frontal lobe	UBERON:0002810	54.09	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Mechanically, we demonstrated that hsa_circ_0001368 served as a competing endogenous RNA (ceRNA) to sponge miR-6506-5p in gastric cancers. (PMID:30853185)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.