MIR6508

Summary

MIR6508 (microRNA 6508, HGNC:50217) is a microRNA gene on chromosome 21q22.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466972 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50217
Approved symbol	MIR6508
Name	microRNA 6508
Location	21q22.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6508
Ensembl gene	ENSG00000275523
Ensembl biotype	miRNA
Entrez	102466972
RNAcentral	URS000075EF3A — ncRNA, 60 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000611656

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000611656 — 1 exons

Exon	Start	End
ENSE00003745719	39447010	39447069

Expression profiles

Bgee: expression breadth broad, 56 present calls, max score 80.08.

Top tissues by expression

56 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	80.08	gold quality
adrenal tissue	UBERON:0018303	76.65	gold quality
blood	UBERON:0000178	74.53	gold quality
muscle of leg	UBERON:0001383	74.33	gold quality
endometrium	UBERON:0001295	72.58	gold quality
rectum	UBERON:0001052	71.82	gold quality
stomach	UBERON:0000945	71.36	gold quality
body of pancreas	UBERON:0001150	70.62	gold quality
gastrocnemius	UBERON:0001388	70.50	gold quality
skin of abdomen	UBERON:0001416	69.89	gold quality
tibial artery	UBERON:0007610	69.67	gold quality
thoracic aorta	UBERON:0001515	69.04	gold quality
right atrium auricular region	UBERON:0006631	68.58	gold quality
heart	UBERON:0000948	68.33	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.08	gold quality
substantia nigra	UBERON:0002038	68.04	gold quality
right lobe of thyroid gland	UBERON:0001119	67.99	gold quality
ascending aorta	UBERON:0001496	67.96	gold quality
subcutaneous adipose tissue	UBERON:0002190	67.49	gold quality
transverse colon	UBERON:0001157	67.39	gold quality
skin of leg	UBERON:0001511	67.03	gold quality
fallopian tube	UBERON:0003889	66.87	gold quality
body of stomach	UBERON:0001161	66.83	gold quality
adult mammalian kidney	UBERON:0000082	66.81	gold quality
heart left ventricle	UBERON:0002084	66.47	gold quality
anterior cingulate cortex	UBERON:0009835	66.34	gold quality
esophagus mucosa	UBERON:0002469	66.24	gold quality
omental fat pad	UBERON:0010414	66.19	gold quality
muscle layer of sigmoid colon	UBERON:0035805	65.87	gold quality
amygdala	UBERON:0001876	65.67	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.99

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• observations collectively demonstrate that AF119895 modulates the repression of NXF3 by binding to miR-6508-3p (PMID:29274323)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.