MIR6509

Summary

MIR6509 (microRNA 6509, HGNC:50207) is a microRNA gene on chromosome 7q33.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465254 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50207
Approved symbol	MIR6509
Name	microRNA 6509
Location	7q33
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6509
Ensembl gene	ENSG00000277138
Ensembl biotype	miRNA
Entrez	102465254
RNAcentral	URS000075EB17 — miRNA, 85 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000614603

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000614603 — 1 exons

Exon	Start	End
ENSE00003724358	135206994	135207078

Expression profiles

Bgee: expression breadth broad, 88 present calls, max score 80.58.

Top tissues by expression

88 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	80.58	gold quality
bone marrow	UBERON:0002371	79.87	gold quality
endometrium	UBERON:0001295	79.19	gold quality
monocyte	CL:0000576	78.16	gold quality
muscle of leg	UBERON:0001383	75.90	gold quality
gastrocnemius	UBERON:0001388	74.39	gold quality
blood	UBERON:0000178	73.32	gold quality
islet of Langerhans	UBERON:0000006	72.97	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	71.86	gold quality
body of stomach	UBERON:0001161	71.77	gold quality
pancreas	UBERON:0001264	71.36	gold quality
stomach	UBERON:0000945	70.92	gold quality
body of pancreas	UBERON:0001150	70.81	gold quality
adult mammalian kidney	UBERON:0000082	70.51	gold quality
fundus of stomach	UBERON:0001160	70.22	gold quality
right ovary	UBERON:0002118	69.93	gold quality
tibial artery	UBERON:0007610	69.63	gold quality
right atrium auricular region	UBERON:0006631	69.07	gold quality
ascending aorta	UBERON:0001496	69.00	gold quality
endocervix	UBERON:0000458	68.95	gold quality
thoracic aorta	UBERON:0001515	68.82	gold quality
myometrium	UBERON:0001296	68.80	gold quality
heart	UBERON:0000948	68.79	gold quality
amygdala	UBERON:0001876	68.64	gold quality
granulocyte	CL:0000094	68.61	gold quality
skin of abdomen	UBERON:0001416	68.32	gold quality
heart left ventricle	UBERON:0002084	68.31	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.28	gold quality
left coronary artery	UBERON:0001626	68.22	gold quality
liver	UBERON:0002107	68.21	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.08

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• LncRNA HOXA10-AS functions as an oncogene by binding miR-6509-5p to upregulate Y-box binding protein 1 in gastric cancer. (PMID:35521747)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.