MIR651

Summary

MIR651 (microRNA 651, HGNC:32907) is a microRNA gene on chromosome Xp22.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 723779 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32907
Approved symbol	MIR651
Name	microRNA 651
Location	Xp22.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-651
Ensembl gene	ENSG00000207628
Ensembl biotype	miRNA
Entrez	723779
RNAcentral	URS0000651B6D — miRNA, 97 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384896

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384896 — 1 exons

Exon	Start	End
ENSE00001499903	8126965	8127061

Expression profiles

Bgee: expression breadth broad, 30 present calls, max score 79.21.

Top tissues by expression

30 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
heart	UBERON:0000948	79.21	gold quality
intestine	UBERON:0000160	78.35	gold quality
blood	UBERON:0000178	77.08	gold quality
kidney	UBERON:0002113	76.39	gold quality
gastrocnemius	UBERON:0001388	74.46	gold quality
adrenal tissue	UBERON:0018303	71.85	gold quality
muscle layer of sigmoid colon	UBERON:0035805	71.21	gold quality
esophagus mucosa	UBERON:0002469	71.15	gold quality
colon	UBERON:0001155	70.07	gold quality
right lobe of thyroid gland	UBERON:0001119	69.27	gold quality
lung	UBERON:0002048	69.08	gold quality
left ovary	UBERON:0002119	69.02	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.68	gold quality
vagina	UBERON:0000996	67.17	gold quality
left adrenal gland	UBERON:0001234	66.98	gold quality
skin of leg	UBERON:0001511	66.54	gold quality
nucleus accumbens	UBERON:0001882	66.53	gold quality
skin of abdomen	UBERON:0001416	65.69	gold quality
thoracic aorta	UBERON:0001515	65.24	gold quality
ascending aorta	UBERON:0001496	64.94	gold quality
putamen	UBERON:0001874	64.91	gold quality
right ovary	UBERON:0002118	64.47	gold quality
thyroid gland	UBERON:0002046	63.54	gold quality
left lobe of thyroid gland	UBERON:0001120	62.24	gold quality
spleen	UBERON:0002106	61.55	gold quality
stomach	UBERON:0000945	61.53	gold quality
tibial nerve	UBERON:0001323	60.47	gold quality
caudate nucleus	UBERON:0001873	57.08	gold quality
testis	UBERON:0000473	46.92	gold quality
left testis	UBERON:0004533	44.98	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• Cancer-Derived Exosomal miR-651 as a Diagnostic Marker Restrains Cisplatin Resistance and Directly Targets ATG3 for Cervical Cancer. (PMID:34567283)
• LncRNA ST8SIA6-AS1 facilitates hepatocellular carcinoma progression by governing miR-651-5p/TM4SF4 axis. (PMID:35946523)
• microRNA-651-5p affects the proliferation, migration, and invasion of lung cancer cells by regulating Calmodulin 2 expression. (PMID:37470336)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.