MIR6510

Summary

MIR6510 (microRNA 6510, HGNC:50101) is a microRNA gene on chromosome 17q21.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466658 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50101
Approved symbol	MIR6510
Name	microRNA 6510
Location	17q21.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6510
Ensembl gene	ENSG00000283796
Ensembl biotype	miRNA
Entrez	102466658
RNAcentral	URS000075DD93 — ncRNA, 54 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000613845

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000613845 — 1 exons

Exon	Start	End
ENSE00003722435	41517164	41517217

Expression profiles

Bgee: expression breadth broad, 71 present calls, max score 96.92.

Top tissues by expression

71 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lower esophagus mucosa	UBERON:0035834	96.92	gold quality
esophagus mucosa	UBERON:0002469	95.84	gold quality
vagina	UBERON:0000996	94.38	gold quality
esophagus	UBERON:0001043	94.21	gold quality
skin of leg	UBERON:0001511	89.76	gold quality
zone of skin	UBERON:0000014	89.24	gold quality
skin of abdomen	UBERON:0001416	88.61	gold quality
prostate gland	UBERON:0002367	87.62	gold quality
thoracic mammary gland	UBERON:0005200	86.81	gold quality
minor salivary gland	UBERON:0001830	84.19	gold quality
saliva-secreting gland	UBERON:0001044	84.11	gold quality
ectocervix	UBERON:0012249	82.54	gold quality
tonsil	UBERON:0002372	79.72	gold quality
right atrium auricular region	UBERON:0006631	79.64	gold quality
subcutaneous adipose tissue	UBERON:0002190	79.24	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	78.34	gold quality
rectum	UBERON:0001052	78.05	gold quality
heart left ventricle	UBERON:0002084	77.32	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	76.87	gold quality
urinary bladder	UBERON:0001255	76.65	gold quality
blood	UBERON:0000178	75.82	gold quality
gastrocnemius	UBERON:0001388	75.44	gold quality
lower esophagus muscularis layer	UBERON:0035833	73.26	gold quality
body of pancreas	UBERON:0001150	73.01	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	72.63	gold quality
substantia nigra	UBERON:0002038	72.16	gold quality
stomach	UBERON:0000945	71.67	gold quality
body of stomach	UBERON:0001161	71.25	gold quality
left ovary	UBERON:0002119	71.07	gold quality
anterior cingulate cortex	UBERON:0009835	70.90	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.13

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.