MIR6511A4

Summary

MIR6511A4 (microRNA 6511a-4, HGNC:50188) is a microRNA gene on chromosome 16p12.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465684 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50188
Approved symbol	MIR6511A4
Name	microRNA 6511a-4
Location	16p12.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6511a-4
Ensembl gene	ENSG00000273613
Ensembl biotype	miRNA
Entrez	102465684
RNAcentral	URS000075BCEB — miRNA, 67 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000615860

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000615860 — 1 exons

Exon	Start	End
ENSE00003728645	18344013	18344079

Expression profiles

Bgee: expression breadth broad, 33 present calls, max score 62.63.

Top tissues by expression

33 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
heart left ventricle	UBERON:0002084	62.63	gold quality
right atrium auricular region	UBERON:0006631	62.55	gold quality
gastrocnemius	UBERON:0001388	61.36	gold quality
amygdala	UBERON:0001876	58.33	gold quality
prefrontal cortex	UBERON:0000451	57.20	gold quality
body of stomach	UBERON:0001161	56.75	gold quality
omental fat pad	UBERON:0010414	55.68	gold quality
muscle layer of sigmoid colon	UBERON:0035805	54.66	gold quality
tibial artery	UBERON:0007610	54.27	gold quality
skin of leg	UBERON:0001511	54.22	gold quality
lower esophagus muscularis layer	UBERON:0035833	53.59	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	52.77	gold quality
tibial nerve	UBERON:0001323	52.69	gold quality
transverse colon	UBERON:0001157	52.28	gold quality
anterior cingulate cortex	UBERON:0009835	51.79	gold quality
putamen	UBERON:0001874	51.06	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	51.03	gold quality
subcutaneous adipose tissue	UBERON:0002190	50.47	gold quality
right frontal lobe	UBERON:0002810	50.35	gold quality
caudate nucleus	UBERON:0001873	50.22	gold quality
skin of abdomen	UBERON:0001416	49.65	gold quality
Ammon’s horn	UBERON:0001954	49.43	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	49.06	gold quality
right hemisphere of cerebellum	UBERON:0014890	48.11	gold quality
hypothalamus	UBERON:0001898	47.71	gold quality
cerebellar hemisphere	UBERON:0002245	47.64	silver quality
substantia nigra	UBERON:0002038	47.18	gold quality
left ovary	UBERON:0002119	47.00	gold quality
Brodmann (1909) area 9	UBERON:0013540	46.65	silver quality
adenohypophysis	UBERON:0002196	45.66	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (3): MIR6511A1 (ENSG00000275259), MIR6511A3 (ENSG00000276311), MIR6511A2 (ENSG00000278221)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.